Y. Takeuchi

Label-free imaging of intracellular structures in living mammalian cells via external apodization phase-contrast microscopy

This study introduces ExAPC microscopy for label-free visualization of intracellular structures, showing its ability to resolve biomolecular condensates, lipid droplets, and mitochondria with high spatiotemporal resolution.

Selective elimination of CD169+ macrophages in lymph nodes invaded by breast cancers

This study shows metastasized breast cancer cells eliminate CD169+ macrophages from lymph nodes, impairing anti-cancer immunity.

Early acquisition of S-specific Tfh clonotypes after SARS-CoV-2 vaccination is associated with the longevity of anti-S antibodies

The paper investigates how early acquisition of S-specific Tfh clonotypes after SARS-CoV-2 vaccination correlates with sustained anti-S antibody levels.

Deletion or inhibition of PTPRO mitigates diet-induced hepatic steatosis and inflammation in obesity

This study shows that deleting or inhibiting PTPRO reduces hepatic steatosis and inflammation in obese mice, improving metabolic health.

Distantly related hepaciviruses share common entry factor, Claudin-1

This study identifies Claudin-1 as a shared entry factor for HCV and GBV-B, showing distinct mechanisms for each virus.

Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina

This study shows Banp is essential for DNA damage response and chromosome segregation in zebrafish retina, preventing mitotic defects and apoptosis.

Characterisation of a novel ACE2-based therapeutic with enhanced rather than reduced activity against SARS-CoV2 variants

The paper characterizes a novel ACE2-based therapeutic that effectively neutralizes SARS-CoV-2 variants and demonstrates antibody-like properties and manufacturability.

Rats show a preference for certain unfamiliar strains of rats

This study shows that Wistar rats preferentially interact with unfamiliar rats of certain strains, suggesting they recognize social similarity based on strain.

MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells

This study shows that MCM10 compensates for c-Myc-induced DNA replication stress in breast cancer stem-like cells, promoting genome duplication and drug resistance.

Role of the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral obstruction in mice

This study investigates the role of LTB4-BLT1 signaling in kidney fibrosis after unilateral ureteral obstruction in mice, finding that BLT1 inhibition reduces fibrosis markers.

Characterisation of Antibody Interactions with the G Protein of Vesicular Stomatitis Virus Indiana Strain and Other Vesiculovirus G Proteins

This paper characterizes two monoclonal antibodies against VSVind.G and their cross-reactivity with other vesiculovirus G proteins, identifying binding epitopes and neutralization mechanisms.