Author

J. Schinkel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

K. Sliepen· 4 shared A. B. Ward· 3 shared R. W. Sanders· 3 shared A. Chumbe· 2 shared J. Capella-Pujol· 2 shared J. L. Torres· 2 shared L. Radic· 2 shared M. Brinkkemper· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersMicrobiology

K. Sliepen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Broadening sarbecovirus neutralization with bispecific antibodies combining distinct conserved targets on the receptor binding domain

D. Guerra, L. Radic, M. Brinkkemper, M. Poniman, L. van der Maas, J. L. Torres, A. B. Ward, K. Sliepen, J. Schinkel, R. W. Sanders, M. J. van Gils, T. Beaumont

This study develops bispecific antibodies that target conserved regions on the SARS-CoV-2 spike protein, showing improved neutralization breadth against multiple sarbecovirus strains.

bioRxiv · May 9, 2024Microbiology

Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses

L. Radic, K. Sliepen, V. Yin, M. Brinkkemper, J. Capella-Pujol, A. I. Schriek, J. L. Torres, S. Bangaru, J. A. Burger, M. Poniman, I. Bontjer, J. H. Bouhuijs, D. Gideonse, D. Eggink, A. B. Ward, , J. Schinkel

This study shows bispecific antibodies combine the neutralizing breadth and potency of parental antibodies to neutralize SARS-CoV and SARS-CoV-2 variants, including Omicron.

bioRxiv · Nov 11, 2022Immunology

Structure of the hepatitis C virus E1E2 glycoprotein complex

A. Torrents de la Pena, K. Sliepen, L. Eshun-Wilson, M. Newby, J. D. Allen, S. Koekkoek, I. Zon, A. Chumbe, M. Crispin, J. Schinkel, G. C. Lander, R. W. Sanders, A. B. Ward

The paper presents the cryo-EM structure of the HCV E1E2 glycoprotein complex with antibodies, revealing the E1-E2 interface and its stabilization mechanisms.

bioRxiv · Dec 16, 2021 · PreprintImmunology

Optimised cell systems for the investigation ofhepatitis C virus E1E2 glycoproteins

M. D. Kalemera, J. Capella-Pujol, A. Chumbe, A. Underwood, R. A. Bull, J. Schinkel, K. Sliepen, J. Grove

This paper identifies an optimized cell line for producing HCV pseudoparticles and reveals antigenic differences between sE2 produced in 293T and 293F cells.

bioRxiv · Jun 18, 2020 · PreprintMicrobiology

High resolution evolutionary analysis of within-host hepatitis C virus infection

J. Raghwani, C.-H. Wu, C. K. Ho, M. de Jong, R. Molenkamp, J. Schinkel, O. G. Pybus, K. A. Lythgoe

This study analyzes within-host HCV evolution in HIV-coinfected individuals, finding population structure, regional variation in mutation rates, and a low recombination rate.

bioRxiv · Aug 28, 2018Evolutionary Biology