Author

J. H. Smit

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Economou· 3 shared S. Karamanou· 3 shared A. Portaliou· 2 shared A.-N. Bondar· 2 shared G. Gouridis· 2 shared K. E. Chatzi· 2 shared K. Karathanou· 2 shared N. Eleftheriadis· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersBiochemistry

A. Economou

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Author profile →

3 papers

Recent·Most cited

Evolutionary adaptation of the folding pathway for secretability

D. Smets, A. Tsirigotaki, J. H. Smit, S. Krishnamurthy, A. Portaliou, A. Vorobieva, W. Vranken, S. Karamanou, A. Economou

This study identifies structural features that delay folding in secretory proteins, enabling their translocation, by comparing PpiA and PpiB.

bioRxiv · Apr 3, 2022 · PreprintBiochemistry

Preproteins couple the intrinsic dynamics of SecA to its ATPase cycle to translocate via a catch and release mechanism

S. Krishnamurthy, M. F. Sardis, N. Eleftheriadis, K. E. Chatzi, J. H. Smit, K. Karathanou, G. Gouridis, A. G. Portaliou, A.-N. Bondar, S. Karamanou, A. Economou

The paper reveals how SecA's intrinsic dynamics and preprotein interactions enable translocation via a catch and release mechanism.

bioRxiv · Aug 31, 2021Biochemistry

A nexus of intrinsic dynamics underlies translocase priming

S. Krisnamurthy, N. Eleftheriadis, K. Karathanou, J. H. Smit, A. Portaliou, K. E. Chatzi, S. Karamanou, A.-N. Bondar, G. Gouridis, A. Economou

This study identifies a dynamic nexus in SecA that primes the Sec translocase for preprotein binding through conserved structural motions and interactions.

bioRxiv · Jan 18, 2021Biochemistry