Author

A. Economou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Biophysics· 2 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:protein folding & dynamics· 4 Organism:bacteria (other)· 3 Approach:experimental assay· 3 Approach:biophysical modeling· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1

Frequent Co-Authors

S. Karamanou· 5 shared G. Gouridis· 3 shared J. H. Smit· 3 shared N. Eleftheriadis· 3 shared A. Portaliou· 2 shared A. Tsirigotaki· 2 shared A.-N. Bondar· 2 shared K. E. Chatzi· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersBiochemistry

S. Karamanou

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Oxygen-induced chromophore degradation in the photoswitchable red fluorescent protein rsCherry

T. Y. H. Bui, E. De Zitter, B. Moeyaert, L. Pecqueur, B. Y. Srinivasu, A. Economou, M. Fontecave, L. Van Meervelt, P. Dedecker, B. Pedre

The paper investigates oxygen-induced chromophore degradation in rsCherry, identifying cleavage of the p-hydroxyphenyl ring and formation of cyclic structures as the cause of fluorescence loss.

bioRxiv · Jan 13, 2023Biophysics

Evolutionary adaptation of the folding pathway for secretability

D. Smets, A. Tsirigotaki, J. H. Smit, S. Krishnamurthy, A. Portaliou, A. Vorobieva, W. Vranken, S. Karamanou, A. Economou

This study identifies structural features that delay folding in secretory proteins, enabling their translocation, by comparing PpiA and PpiB.

bioRxiv · Apr 3, 2022 · PreprintBiochemistry

Preproteins couple the intrinsic dynamics of SecA to its ATPase cycle to translocate via a catch and release mechanism

S. Krishnamurthy, M. F. Sardis, N. Eleftheriadis, K. E. Chatzi, J. H. Smit, K. Karathanou, G. Gouridis, A. G. Portaliou, A.-N. Bondar, S. Karamanou, A. Economou

The paper reveals how SecA's intrinsic dynamics and preprotein interactions enable translocation via a catch and release mechanism.

bioRxiv · Aug 31, 2021Biochemistry

A nexus of intrinsic dynamics underlies translocase priming

S. Krisnamurthy, N. Eleftheriadis, K. Karathanou, J. H. Smit, A. Portaliou, K. E. Chatzi, S. Karamanou, A.-N. Bondar, G. Gouridis, A. Economou

This study identifies a dynamic nexus in SecA that primes the Sec translocase for preprotein binding through conserved structural motions and interactions.

bioRxiv · Jan 18, 2021Biochemistry

Small-molecule antibiotic inhibitors of post-translational protein secretion

A. Economou, E. Burchacka, L. Angus, A. Marchand, M. B. Hamed, J. De Geyter, M. S. Loos, J. Anne, H. Klaassen, P. Chaltin, S. Karamanou

This study identifies small-molecule inhibitors of the bacterial Sec secretion pathway through a high-throughput screen, revealing compounds with antibacterial activity against multiple Gram-positive and Gram-negative species.

bioRxiv · Nov 17, 2020 · PreprintMicrobiology

Evolution of structural dynamics in bilobed proteins

G. Gouridis, Y. Muthahari, M. de Boer, K. Tassis, A. Tsirigotaki, N. Zijlstra, N. Eleftheriadis, R. Xu, M. Zacharias, D. A. Griffith, Y. Sugijo, A. Doemling, S. Karamanou, A. Economou, T. Cordes

The paper investigates how structural dynamics in bilobed proteins evolve, showing that modifications to the structural core enable functional diversification through altered interdomain interactions and substrate specificity.

bioRxiv · Oct 19, 2020 · PreprintBiophysics