Author

A. M. Toye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Approach:genetic perturbation / CRISPR· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

T. J. Satchwell· 3 shared N. R. King· 2 shared P. L. Moura· 2 shared A. Boussahel· 1 shared A. D'Alessandro· 1 shared A. W. Perriman· 1 shared C. de Kergariou· 1 shared C. E. Severn· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCell Biology

T. J. Satchwell

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The Immobilization of Hyaluronic Acid in 3D Hydrogel Scaffolds Modulates Macrophage Polarization

T. C. L. Oates, J. Boyd, L. Dolan, C. de Kergariou, A. M. Toye, A. W. Perriman, A. Boussahel

This paper shows that varying hyaluronic acid molecular weight in collagen-HA hydrogels can direct macrophage polarization, but chemical crosslinking of HA prevents this effect.

bioRxiv · Apr 10, 2024Bioengineering

Complete absence of GLUT1 does not impair human terminal erythroid differentiation

C. Martins Freire, N. R. King, M. Dzieciatkowska, D. Stephenson, P. L. Moura, J. G. G. Dobbe, G. J. Streekstra, A. D'Alessandro, A. M. Toye, T. J. Satchwell

This study shows that complete absence of GLUT1 in human erythroid cells does not impair differentiation or membrane properties, but leads to metabolic changes and increased oxidative stress.

bioRxiv · Jan 10, 2024 · PreprintCell Biology

Basigin mediation of Plasmodium falciparum red blood cell invasion does not require its interaction with monocarboxylate transporter 1

N. R. King, C. M. Freire, J. Touhami, M. Sitbon, A. M. Toye, T. J. Satchwell

The paper shows that Plasmodium falciparum invasion of red blood cells does not require basigin's interaction with MCT1, as invasion remains unaffected by disrupting this interaction or removing the basigin transmembrane domain.

bioRxiv · Oct 26, 2023 · PreprintCell Biology

Characterizing the polarization continuum of macrophage subtypes M1, M2a and M2c

T. C. Oates, P. L. Moura, S. J. Cross, K. Roberts, H. E. Baum, K. Haydn-Smith, M. C. Wilson, K. J. Heesom, C. E. Severn, A. M. Toye

This study characterizes four macrophage subtypes using proteomics and functional assays, showing M2c macrophages upregulate pro-inflammatory markers and dexamethasone induces partial repolarization from M1 to M2c.

bioRxiv · Jun 13, 2022Immunology

Stable knockout and complementation of receptor expression using in vitro cell line derived reticulocytes for dissection of host malaria invasion requirements

T. J. Satchwell, K. E. Wright, K. L. Haydn-Smith, F. S.-R. Teran, J. Hawksworth, J. Frayne, A. M. Toye, J. Baum

This study uses reticulocytes from an immortalized erythroblast cell line to investigate host receptor roles in malaria invasion, showing basigin's essential function and cyclophilin B's non-requirement.

bioRxiv · Dec 13, 2018Cell Biology