Author

J. J. Adams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. S. Sidhu· 3 shared L. L. Blazer· 2 shared A. A. Kossiakoff· 1 shared A. D. Leavitt· 1 shared A. Naik· 1 shared A. P. Wiita· 1 shared A. Sinz· 1 shared A. U. Singer· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiochemistry

S. S. Sidhu

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Engineered Antigen-Binding Fragments for Enhanced Crystallisation of Antibody:Antigen Complexes

H. A. Bruce, A. U. Singer, E. V. Filippova, L. L. Blazer, J. J. Adams, L. Enderle, M. Ben-David, E. H. Radley, D. Y. Mao, V. Pau, S. Orlicky, F. Sicheri, I. Kourinov, S. Atwell, A. A. Kossiakoff, S. S. Sidhu

This study identifies surface substitutions that enhance the crystallisation of Fab:antigen complexes by combining surface entropy reduction with phage-display technology and previously reported substitutions.

bioRxiv · Jul 6, 2023 · PreprintBiochemistry

Structural surfaceomics reveals an AML-specific conformation of Integrin-β2 as a CAR-T therapy target

K. Mandal, G. Wicaksono, C. Yu, J. J. Adams, M. R. Hoopmann, W. C. Temple, B. P. Escobar, M. Gorelik, C. H. Ihling, M. A. Nix, A. Naik, E. Ramos, C. Kasap, V. Steri, J. A. C. Serrano, , A. P. Wiita

The paper identifies an AML-specific conformation of Integrin-β2 using structural surfaceomics and demonstrates its targeting by CAR-T cells.

bioRxiv · Oct 10, 2022 · PreprintCancer Biology

Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling

S. C. Griffiths, J. Tan, A. Wagner, L. L. Blazer, J. J. Adams, S. Srinivasan, S. Moghisaei, S. S. Sidhu, C. Siebold, H.-Y. H. Ho

This study determines the structure of ROR2's CRD and Kr domains, revealing a novel mechanism for WNT5A signaling and identifying the CRD's role in ROR2 function and secretion.

bioRxiv · Jul 26, 2021Biochemistry