A. Naik

Glomerular Elastic Modulus and Gene Expression PatternsDefine Two Phases of Alport Nephropathy

This study identifies early glomerular changes and gene expression patterns in Alport syndrome, showing ER stress and four genes as key drivers of disease before proteinuria, and highlights potential therapeutic targets.

Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma

The paper identifies tumor-specific alternative splicing events in glioma that could generate cell-surface antigens but finds significant spatiotemporal heterogeneity and lack of proteomic evidence.

Klebsiella Pneumoniae turns more virulent under flow stresses in capillary like microchannels

This study shows that Klebsiella pneumoniae becomes more virulent under flow stresses in microchannels, as evidenced by increased proliferation in macrophages.

Parallel, Continuous Monitoring and Quantification of Programmed Cell Death in Plant Tissue

This study introduces PASTEL, a platform for continuous HR cell death monitoring in plants, achieving high accuracy in classification using machine learning.

Modulation of SLFN11 induces changes in DNA Damage response

This study shows that increasing SLFN11 expression through CRISPR-dCas9 systems enhances DNA damage response sensitivity in breast cancer cells.

Time-Resolved Chemical Phenotyping of Whole Plant Roots with Printed Electrochemical Sensors and Machine Learning

This paper introduces TETRIS, a real-time chemical phenotyping platform for monitoring root environment chemistry in plants, and uses machine learning to predict ion uptake rates.

Structural surfaceomics reveals an AML-specific conformation of Integrin-β2 as a CAR-T therapy target

The paper identifies an AML-specific conformation of Integrin-β2 using structural surfaceomics and demonstrates its targeting by CAR-T cells.

Circadian regulation of lung repair and regeneration

This study shows that the circadian clock regulates lung repair and regeneration independently of inflammation, identifies the Wnt/β-catenin pathway as a mediator, and links poor circadian rhythms to worse lung infection outcomes.

Targeting LDHC dysregulates the cell cycle and improves sensitivity to cisplatin and olaparib

This study shows that targeting LDHC disrupts the cell cycle and enhances sensitivity to cisplatin and olaparib in breast cancer cells.

Quantifying Climatic and Socio-Economic Influences on Urban Malaria in Surat, India: A Modelling Study

This study quantifies the joint influence of climate and socio-economic factors on urban malaria risk in Surat, India, using spatio-temporal modeling across multiple spatial resolutions.

An Automated Addressable Microfluidics Device for Minimally-Invasive Manipulation of Cells and Fluids within Living Cultures

This paper introduces an automated microfluidics device for minimally invasive cell and fluid manipulation in living cultures, enabling better tissue engineering and monitoring.

Enhanced cytokine responsiveness in natural killer cells from a pilot cohort of uninfected seronegative women exposed to hepatitis C virus contaminated anti-D immunoglobulin

The study examines innate immune mechanisms in ESN individuals exposed to HCV via contaminated anti-D immunoglobulin, finding enhanced NK cell cytokine responsiveness.

Protein phosphatase 1 down regulates ZYG-1 levels to limit centrioleduplication

The paper identifies PP1 as a regulator of ZYG-1 levels in C. elegans, showing that reduced PP1 activity increases ZYG-1 and leads to centriole amplification.