M. E. Peeples

A 3D Printed Ventilated Perfused Lung Model Platform to Dissect the Lung's Response to Viral Infection in the Presence of Respiration

This study develops a 3D printed lung model to investigate how ventilation affects viral infection and lung responses in vitro.

Neuregulin-1 protects against respiratory viral induced mortality

This study shows that Neuregulin-1 (NRG1) protects against respiratory viral mortality by reducing viral replication and epithelial permeability in both mice and human cells.

High-Throughput Bioprinting of the Nasal Epithelium using Patient-derived Nasal Epithelial Cells

This study uses 3D bioprinting to create nasal epithelium models from patient-derived cells, enabling high-throughput fabrication and recapitulating native epithelial architecture and virus infection capability.

Prime-pull immunization of mice with a BcfA-adjuvanted vaccine elicits mucosal immunity and prevents SARS CoV-2 infection and pathology

Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice

This study shows that IFITM3 protects mice from severe SARS-CoV-2 infection by limiting viral spread and inflammation, as demonstrated through knockout mouse models.

SARS-CoV-2 Spreads through Cell-to-Cell Transmission

This study shows SARS-CoV-2 spreads through cell-to-cell contact via spike glycoprotein, which is more efficient than SARS-CoV and resistant to neutralizing antibodies.

Synchronization Temperature Determines the Location of RSV Fusion During Entry in Cultured Cells

This study shows that RSV fusion occurs at the plasma membrane when cells are warmed to 37°C from 22°C, but at the endosome when warmed from 4°C, suggesting the latter is an experimental artifact.

Mathematical Modeling Identifies the Role of Adaptive Immunity as a Key Controller of Respiratory Syncytial Virus (RSV) Titer in Cotton Rats

The paper uses mathematical modeling to show that adaptive immunity significantly reduces RSV titer in cotton rats, with key kinetic features observed in both in vitro and in vivo experiments.