Author

A. D. Kenney

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:human· 5 Organism:mouse· 3 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

J. S. Yount· 6 shared L. Zhang· 3 shared A. Zani· 2 shared P. J. Denz· 2 shared S. Speaks· 2 shared A. A. S. Compton· 1 shared A. Biswas· 1 shared A. C. Eddy· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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6 shared papersImmunology

J. S. Yount

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Author profile →

6 papers

Recent·Most cited

Innate immune control of influenza virus interspecies adaptation

P. J. Denz, S. Speaks, A. D. Kenney, A. C. Eddy, J. L. Papa, J. Roettger, S. C. Scace, E. A. Hemann, A. Forero, R. J. Webby, A. S. Bowman, J. S. Yount

This study shows that IFITM3 deficiency in mice allows avian influenza viruses to infect and adapt more effectively, suggesting a role for IFITM3 in preventing zoonotic virus emergence.

bioRxiv · Aug 23, 2023 · PreprintMicrobiology

Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis

A. D. Kenney, S. L. Aron, C. Gilbert, N. Kumar, P. Chen, A. Eddy, L. Zhang, A. Zani, N. Vargas-Maldonado, S. Speaks, J. Kawahara, P. J. Denz, L. Dorn, F. Accornero, J. Ma, , J. S. Yount

This study shows that influenza virus directly infects cardiomyocytes, causing heart dysfunction and fibrosis, challenging the prevailing model of indirect cardiotoxicity.

bioRxiv · Oct 27, 2021Immunology

SARS-CoV-2 Nsp14 activates NF-κB signaling and induces IL-8 upregulation

T.-W. Li, A. D. Kenney, H. Liu, G. N. Fiches, D. Zhou, A. Biswas, J. Que, N. Santoso, J. S. Yount, J. Zhu

This study shows that SARS-CoV-2 Nsp14 activates NF-κB signaling and increases IL-8 expression, which is confirmed in infected cells and lung tissue from COVID-19 patients.

bioRxiv · May 26, 2021 · PreprintMicrobiology

Moderately pathogenic maternal influenza A virus infection disrupts placental integrity but spares the fetal brain

A. M. Antonson, A. D. Kenney, H. J. Chen, K. N. Corps, J. S. Yount, T. L. Gur

This study shows that moderate maternal influenza A virus infection causes placental issues but not fetal brain inflammation in mice.

bioRxiv · Jan 22, 2021Immunology

Opposing activities of IFITM proteins in SARS-CoV-2 infection

G. Shi, A. D. Kenney, E. Kudryashova, L. Zhang, L. Hall-Stoodley, R. Robinson, D. Kudryashov, A. A. S. Compton, J. S. Yount

This study identifies opposing roles of IFITM3 in restricting and enhancing SARS-CoV-2 infection through distinct mechanisms involving endosomal restriction and plasma membrane fusion.

bioRxiv · Aug 11, 2020Immunology

IFITM3 restricts human metapneumovirus infection

T. M. McMichael, Y. Zhang, A. D. Kenney, L. Zhang, A. Zani, M. Lu, M. Chemudupati, J. Li, J. S. Yount

This study identifies IFITM3 and TLR7 as endosomal factors that differentially regulate hMPV infection, with IFITM3 restricting it and TLR7 enhancing it in some strains.

bioRxiv · Jun 7, 2018Immunology