Author

B. W. Anderson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 3 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cell signaling & trafficking· 1 Assay:proteomics· 1

Frequent Co-Authors

J. D. Wang· 4 shared A. Turdiev· 2 shared H. Turdiev· 2 shared J. Yang· 2 shared K. A. Satyshur· 2 shared V. T. Lee· 2 shared A. Hao· 1 shared C. Wolak· 1 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersMicrobiology

J. D. Wang

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4 papers

Recent·Most cited

The nucleotide messenger (p)ppGpp is a co-repressor of the purine synthesis transcription regulator PurR in Firmicutes

B. W. Anderson, M. A. Schumacher, J. Yang, A. Turdiev, H. Turdiev, Q. He, V. T. Lee, R. G. Brennan, J. D. Wang

This study shows (p)ppGpp acts as a co-repressor of PurR in Firmicutes, downregulating purine synthesis by enhancing PurR DNA binding, with implications across environments from the gut to pathogens.

bioRxiv · Dec 2, 2020 · PreprintMicrobiology

Systemic characterization of pppGpp, ppGpp and pGpp targets in Bacillus reveal NahA converts (p)ppGpp to pGpp to regulate alarmone composition and signaling

J. Yang, B. W. Anderson, A. Turdiev, H. Turdiev, D. M. Stevenson, D. Amador-Noguez, V. T. Lee, J. D. Wang

The paper identifies pGpp as a third alarmone in Bacillus and shows NahA converts (p)ppGpp to pGpp, altering alarmone composition and stress response.

bioRxiv · Mar 23, 2020 · PreprintMicrobiology

Molecular mechanism of regulation of the purine salvage enzyme XPRT by the alarmones pppGpp, ppGpp, and pGpp

B. W. Anderson, A. Hao, K. A. Satyshur, J. L. Keck, J. D. Wang

This study identifies how alarmones pppGpp, ppGpp, and pGpp inhibit XPRT activity by competing with PRPP, revealing structural and regulatory differences between XPRT and HPRT.

bioRxiv · Mar 4, 2020Microbiology

Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction

J. D. Wang, B. W. Anderson, K. Liu, C. Wolak, K. Dubiel, K. A. Satyshur, J. Keck

The paper identifies a conserved (p)ppGpp binding motif in HPRT across species, showing that ligand binding varies with dimer-dimer interactions that evolved to regulate purine homeostasis.

bioRxiv · Apr 28, 2019Biochemistry