Author

J. L. Prior

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

N. J. Harmer· 2 shared R. A. Field· 2 shared S. A. Nepogodiev· 2 shared A. E. Scott· 1 shared A. Iliuk· 1 shared A. Noble· 1 shared A. R. Cross· 1 shared A. R. Tipton· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiochemistry

N. J. Harmer

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Breast cancer mutations HER2 V777L and PIK3CA H1047R activate the p21/CDK4/6/Cyclin D1 axis driving tumorigenesis and drug resistance.

X. Cheng, Y. Sun, M. Highkin, N. Vemalapally, X. Jin, B. Zhou, J. L. Prior, A. R. Tipton, S. Li, A. Iliuk, S. Achilefu, I. S. Hagemann, J. R. Edwards, R. Bose

This study investigates how HER2 V777L and PIK3CA H1047R mutations drive breast cancer tumorigenesis and drug resistance, showing effective combination therapies.

bioRxiv · Nov 9, 2022 · PreprintCancer Biology

Spinning sugars in antigen biosynthesis: a direct study of the Coxiella burnetii and Streptomyces griseus TDP-sugar epimerases

A. R. Cross, S. Roy, M. Vivoli Vega, M. Rejzek, S. A. Nepogodiev, M. Cliff, D. Salmon, M. N. Isupov, R. A. Field, J. L. Prior, N. J. Harmer, Glycoengineering of Veterinary Vaccines (GoVV)

This paper studies the TDP-sugar epimerases in Coxiella burnetii and Streptomyces griseus, showing they perform the RmlC 3,5 double epimerisation activity and support TDP-rhamnose biosynthesis.

bioRxiv · Oct 25, 2021 · PreprintBiochemistry

Role for both myeloid and plasmacytoid DC in driving primary T helper cell response to Burkholderia pseudomallei in healthy individuals.

D. Reddi, L. Durant, D. Bernardo, A. Noble, N. R. English, P. Hendy, G. C. Clark, J. L. Prior, E. D. Williamson, S. C. Knight

This study shows that both myeloid and plasmacytoid dendritic cells activate pro-inflammatory cytokines and drive T helper cell responses to Burkholderia pseudomallei in healthy individuals.

bioRxiv · Jun 22, 2020 · PreprintImmunology

Assessments of hepatitis B virus-like particles and Crm197 as carrier proteins in melioidosis glycoconjugate vaccines

M. Bayliss, G. Pergolizzi, M. I. Donaldson, A. E. Scott, S. A. Nepogodiev, L. Beales, M. Whelan, W. Rosenberg, H. Peyret, G. P. Lomonossoff, N. J. Harmer, T. Atkins, R. A. Field, J. L. Prior

This study compares the effectiveness of Crm197 and hepatitis B virus-like particles as carrier proteins for a melioidosis glycoconjugate vaccine, finding that Crm197 conjugates produce higher antibody titres but both protect against bacterial challenge.

bioRxiv · Apr 8, 2020 · PreprintImmunology