Author

A. R. Cross

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Organism:C. elegans· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

F. Issa· 2 shared J. B. Goldberg· 2 shared J. Hester· 2 shared A. G. Dykema· 1 shared A. J. McAdam· 1 shared A. J. Poret· 1 shared A. S. Meyer· 1 shared A. Young· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioengineering

F. Issa

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

De novo mutations mediate phenotypic switching in an opportunistic human lung pathogen

A. J. Poret, M. M. Schaefers, C. Merakou, K. E. Mansour, G. K. Lagoudas, A. R. Cross, J. B. Goldberg, R. Kishony, A. Z. Uluer, A. J. McAdam, P. C. Blainey, S. O. Vargas, T. D. Lieberman, G. P. Priebe

This study shows that de novo mutations in Burkholderia dolosa cause phenotypic switching, with O-antigen loss increasing immune cell uptake but reducing lung competitiveness, depending on infection duration and tissue localization.

bioRxiv · Feb 6, 2024 · PreprintMicrobiology

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

D. VanDyke, M. Iglesias, J. Tomala, A. Young, J. Smith, J. A. Perry, E. Gebara, A. R. Cross, L. S. Cheung, A. G. Dykema, B. T. Orcutt-Jahns, T. Henclova, J. Golias, J. Balolong, L. M. Tomasovic, , J. B. Spangler

The paper engineers a cytokine/antibody fusion protein that selectively expands regulatory T cells and protects against autoimmune diseases in mouse models.

bioRxiv · May 29, 2022Bioengineering

Spinning sugars in antigen biosynthesis: a direct study of the Coxiella burnetii and Streptomyces griseus TDP-sugar epimerases

A. R. Cross, S. Roy, M. Vivoli Vega, M. Rejzek, S. A. Nepogodiev, M. Cliff, D. Salmon, M. N. Isupov, R. A. Field, J. L. Prior, N. J. Harmer, Glycoengineering of Veterinary Vaccines (GoVV)

This paper studies the TDP-sugar epimerases in Coxiella burnetii and Streptomyces griseus, showing they perform the RmlC 3,5 double epimerisation activity and support TDP-rhamnose biosynthesis.

bioRxiv · Oct 25, 2021 · PreprintBiochemistry

Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury

A. R. Cross, C. de Andrea, M. Villalba-Esparza, M. Landecho Acha, L. Cerundolo, P. Weeratunga, R. Etherington, L. Denney, G. Ogg, L.-P. Ho, I. Roberts, J. Hester, P. Klenerman, I. Melero, S. Sansom, F. Issa

The paper uses spatial transcriptomics to identify immune circuits in severe COVID-19 lung tissue, finding IFNγ response signatures linked to alveolar damage.

bioRxiv · Jun 21, 2021Immunology

Overproduction of the AlgT sigma factor is lethal to mucoid Pseudomonas aeruginosa

A. R. Cross, V. Raghuram, Z. Wang, D. Dey, J. B. Goldberg

This study shows that overproduction of AlgT sigma factor is lethal in mucoid Pseudomonas aeruginosa and identifies mutations in mucP as suppressors that stabilize MucA22 to reduce toxicity.

bioRxiv · Jun 5, 2020Microbiology