Author

J. L. Walshe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:E. coli· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. G. Stewart· 2 shared J. M. Guss· 2 shared J. P. Mackay· 2 shared K. Patel· 2 shared M. Sobti· 2 shared R. Ishmukhametov· 2 shared A. P. G. Silva· 1 shared B. Atto· 1 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiophysics

A. G. Stewart

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Author profile →

5 papers

Recent·Most cited

Subunit epsilon of E. coli F1Fo ATP synthase attenuates enzyme activity by modulating central stalk flexibility

M. Sobti, J. L. Walshe, Y. C. Zeng, R. Ishmukhametov, A. G. Stewart

This study presents cryo-EM structures of E. coli ATP synthase showing how the ε subunit modulates central stalk flexibility to regulate enzyme activity.

bioRxiv · Sep 30, 2020 · PreprintBiophysics

Structural characterization of an RNA bound antiterminator protein reveal a successive binding mode

J. L. Walshe, K. Patel, S. F. Ataide

The paper determines the structure of the ANTAR domain protein EutV bound to an RNA target, revealing a single hexaloop binding mode and redefining the minimal binding motif.

bioRxiv · Sep 27, 2020Biophysics

Cyclic peptides can engage a single binding pocket through multiple, entirely divergent modes

K. Patel, L. J. Walport, J. L. Walshe, P. Solomon, J. K. K. Low, D. H. Tran, K. S. Mouradian, A. P. G. Silva, L. Wilkinson-White, J. M. Matthews, J. M. Guss, R. J. Payne, T. Passioura, H. Suga, J. P. Mackay

The paper identifies high-affinity, specific cyclic peptide inhibitors of BET bromodomains using RaPID screening, revealing diverse binding modes and structures.

bioRxiv · Nov 21, 2019Biochemistry

A heme-binding protein produced by Haemophilus haemolyticus inhibits non-typeable Haemophilus influenzae

R. D. Latham, M. Torrado, B. Atto, J. L. Walshe, R. Wilson, J. M. Guss, J. P. Mackay, S. Tristram, D. A. Gell

This study identifies hemophilin, a heme-binding protein from Haemophilus haemolyticus, which inhibits non-typeable Haemophilus influenzae by heme starvation.

bioRxiv · May 15, 2019Biochemistry

Visualizing movements in E. coli F1Fo ATP synthase indicates how the F1 and Fo motors are coupled

M. Sobti, J. L. Walshe, R. Ishmukhametov, A. G. Stewart

The paper presents high-resolution cryo-EM structures of E. coli F1Fo ATP synthase and describes a rotational sub-step of the Fo motor that explains how the F1 and Fo motors are coupled with minimal energy loss.

bioRxiv · Apr 29, 2019 · PreprintBiophysics