Author

J. P. Mackay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:protein structure· 2 Approach:statistical model· 2 Approach:Bayesian inference· 1

Frequent Co-Authors

J. K. K. Low· 3 shared R. J. Payne· 3 shared A. Norman· 2 shared H. Suga· 2 shared J. K. Low· 2 shared J. L. Walshe· 2 shared J. M. Guss· 2 shared K. Patel· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

J. K. K. Low

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Author profile →

7 papers

Recent·Most cited

Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins

C. Franck, K. Patel, L. J. Walport, M. T. Christie, A. Norman, T. Passioura, R. J. Payne, H. Suga, J. P. Mackay

The paper discovers and characterizes cyclic peptides that selectively bind to the C-terminal bromodomains of BET family proteins, showing high potency and paralogue-specificity.

bioRxiv · Dec 25, 2022Biochemistry

Cross-linking mass spectrometry discovers, evaluates, and validates the experimental and predicted structural proteome

T. K. Bartolec, X. Vazquez-Campos, A. Norman, C. Luong, R. J. Payne, M. R. Wilkins, J. P. Mackay, J. K. K. Low

The paper combines cross-linking mass spectrometry with AI-based structure prediction to discover and validate protein and complex structures at proteome scale.

bioRxiv · Nov 16, 2022 · PreprintBiochemistry

Molecular architecture of nucleosome remodeling and deacetylase sub-complexes by integrative structure determination

S. Arvindekar, M. J. Jackman, J. K. Low, M. J. Landsberg, J. P. Mackay, S. Viswanath

This study determines the molecular architecture of three NuRD sub-complexes using integrative structural methods, revealing new subunit interfaces and MBD3 localization.

bioRxiv · Nov 25, 2021Biophysics

Unique Protein Interaction Networks Define The Chromatin Remodeling Module of The NuRD Complex

M. Sharifi Tabar, C. Giardina, Y. Feng, H. Francis, H. Moghaddassani, J. K. K. Low, J. P. Mackay, C. G. Bailey, J. E. J. Rasko

The paper identifies paralogue-specific protein interactions of the MGCC module in the NuRD complex, revealing mechanisms for functional specificity and integration into other complexes.

bioRxiv · Jan 27, 2021Biochemistry

The Nucleosome Remodeling and Deacetylase complex has an asymmetric, dynamic, and modular architecture

J. K. Low, A. P. Silva, M. Sharifi Tabar, M. Torrado, S. R. Webb, B. L. Parker, M. Sana, C. Smits, J. W. Schmidberger, L. Brillault, M. J. Jackman, D. C. Williams, G. A. Blobel, S. B. Hake, N. E. Shepherd, , J. P. Mackay

This study reveals the asymmetric and dynamic architecture of the NuRD complex using integrated biochemical and structural methods.

bioRxiv · Feb 17, 2020Biochemistry

Cyclic peptides can engage a single binding pocket through multiple, entirely divergent modes

K. Patel, L. J. Walport, J. L. Walshe, P. Solomon, J. K. K. Low, D. H. Tran, K. S. Mouradian, A. P. G. Silva, L. Wilkinson-White, J. M. Matthews, J. M. Guss, R. J. Payne, T. Passioura, H. Suga, J. P. Mackay

The paper identifies high-affinity, specific cyclic peptide inhibitors of BET bromodomains using RaPID screening, revealing diverse binding modes and structures.

bioRxiv · Nov 21, 2019Biochemistry

A heme-binding protein produced by Haemophilus haemolyticus inhibits non-typeable Haemophilus influenzae

R. D. Latham, M. Torrado, B. Atto, J. L. Walshe, R. Wilson, J. M. Guss, J. P. Mackay, S. Tristram, D. A. Gell

This study identifies hemophilin, a heme-binding protein from Haemophilus haemolyticus, which inhibits non-typeable Haemophilus influenzae by heme starvation.

bioRxiv · May 15, 2019Biochemistry