Author

P. Solomon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Biochemistry· 3 Plant Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 5 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:microscopy & imaging analysis· 2 Organism:mouse· 2

Frequent Co-Authors

I. Lui· 3 shared J. A. Wells· 3 shared K. K. Leung· 3 shared N. J. Rettko· 3 shared S. A. Lim· 3 shared X. X. Zhou· 3 shared A. Arora· 2 shared A. Sweeney· 2 shared

Activity by Year

2019-2025 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBioengineering

I. Lui

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10 papers

Recent·Most cited

Vascular regional analysis unveils differential responses to anti-angiogenic therapy in pancreatic xenografts through macroscopic photoacoustic imaging

A. Sweeney, M. Xavierselvan, A. Langley, P. Solomon, A. Arora, S. Mallidi

This study uses macroscopic photoacoustic imaging to analyze vascular regional changes in pancreatic xenografts during anti-angiogenic therapy, identifying differential responses through vascular regional analysis.

Theranostics · Jan 27, 2025Peer-reviewedBioengineering

Impact of ectopic calcification on vascular oxygenation in placental dysfunction models: Simultaneous in vivo assessment with multi-parametric ultrasound and photoacoustic imaging

S. A. Edwards, A. Correia-Branco, D. Sankepalle, A. Arora, A. Sweeney, P. Solomon, M. C. Wallingford, S. Mallidi

bioRxiv · Dec 4, 2023 · PreprintBioengineering

mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome

J. K. Low, K. Patel, P. Solomon, A. Norman, P. Pachl, N. Jones, R. J. Payne, T. Passioura, H. Suga, L. J. Walport, J. Mackay

The paper uses mRNA display to identify high-affinity bromodomain-binding motifs not present in the human proteome, revealing novel binding modes and suggesting evolutionary pressure against strong binders.

bioRxiv · May 17, 2023Biochemistry

Simple and efficient heterologous expression of necrosis-inducing effectors using the model plant Nicotiana benthamiana

B. Dagvadorj, P. Solomon

This paper describes a method to express fungal effector proteins in Nicotiana benthamiana, enabling efficient necrosis induction in host plants.

bioRxiv · May 2, 2021Plant Biology

Remarkable recent changes in genetic diversity of the avirulence gene AvrStb6 in global populations of the wheat pathogen Zymoseptoria tritici

C. Stephens, F. Olmez, H. Blyth, M. McDonald, A. Bansal, E. B. Turgay, F. Hahn, C. Saintenac, V. Nekrasov, P. Solomon, A. Milgate, B. Fraaije, J. J. Rudd, K. Kanyuka

The paper analyzes changes in AvrStb6 genetic diversity in Zymoseptoria tritici isolates from 2013-2017, finding a loss of the original avirulence isoform and dominance of a single virulence isoform.

bioRxiv · Sep 18, 2020Microbiology

Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike

C. J. Bracken, S. A. Lim, P. Solomon, N. J. Rettko, D. P. Nguyen, B. S. Zha, K. Schaefer, J. R. Byrnes, J. Zhou, I. Lui, J. Liu, K. Pance, QCRG Structural Biology Consortium, X. X. Zhou, K. K. Leung, J. A. Wells

This paper identifies and engineers multivalent human VH domains that neutralize SARS-CoV-2 by targeting distinct epitopes on the Spike protein's ACE2 binding interface, showing increased affinity and potency.

bioRxiv · Aug 8, 2020 · PreprintBioengineering

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

A. Glasgow, J. E. Glasgow, D. Limonta, P. Solomon, I. Lui, Y. Zhang, M. A. Nix, N. J. Rettko, S. A. Lim, S. Zha, R. Yamin, K. Kao, O. S. Rosenberg, J. V. Ravetch, A. P. Wiita, , J. A. Wells

This paper describes engineered ACE2 receptor traps that potently neutralize SARS-CoV-2 by blocking viral entry through enhanced binding affinity.

bioRxiv · Jul 31, 2020Bioengineering

The crystal structure of SnTox3 from the necrotrophic fungus Parastagonospora nodorum reveals a unique effector fold and insights into Kex2 protease processing of fungal effectors

M. A. Outram, Y.-C. Sung, D. Yu, B. Dagvadorj, S. Rima, D. Jones, D. J. Ericsson, J. Sperschneider, P. Solomon, B. Kobe, S. J. Williams

The paper determines the crystal structure of SnTox3, a fungal effector, revealing a novel β-barrel fold and showing that it is a pre-pro-protein processed by Kex2 protease.

bioRxiv · May 27, 2020Plant Biology

Trimeric SARS-CoV-2 Spike interacts with dimeric ACE2 with limited intra-Spike avidity

I. Lui, X. X. Zhou, S. A. Lim, S. Elledge, P. Solomon, N. J. Rettko, B. S. Zha, L. L. Kirkemo, J. A. Gramespacher, J. Liu, F. Muecksch, J. C. C. Lorenzi, F. Schmidt, Y. Weisblum, D. F. Robbiani, , J. A. Wells

This study investigates the interaction between SARS-CoV-2 Spike and ACE2, showing that dimeric ACE2 binds with high affinity to Spike and blocks viral entry, with limited intra-Spike avidity.

bioRxiv · May 21, 2020 · PreprintBiochemistry

Cyclic peptides can engage a single binding pocket through multiple, entirely divergent modes

K. Patel, L. J. Walport, J. L. Walshe, P. Solomon, J. K. K. Low, D. H. Tran, K. S. Mouradian, A. P. G. Silva, L. Wilkinson-White, J. M. Matthews, J. M. Guss, R. J. Payne, T. Passioura, H. Suga, J. P. Mackay

The paper identifies high-affinity, specific cyclic peptide inhibitors of BET bromodomains using RaPID screening, revealing diverse binding modes and structures.

bioRxiv · Nov 21, 2019Biochemistry