Author

D. G. Franchina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

D. Brenner· 3 shared H. Kurniawan· 2 shared M. Grusdat· 2 shared A. Baron· 1 shared A. Ewen· 1 shared A. Goerlach· 1 shared A. Petry· 1 shared A. Sipol· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

D. Brenner

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

L. Bonetti, V. Horkova, J. Longworth, L. Guerra, H. Kurniawan, D. G. Franchina, L. Soriano-Baguet, M. Grusdat, S. Spath, E. Koncina, A. Ewen, C. Binsfeld, C. Verscheuren, J.-J. Gerardy, T. Kobayashi, , D. Brenner

This study identifies a Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis that protects against intestinal inflammation by maintaining barrier integrity and preventing mortality from C. rodentium infection.

bioRxiv · Jul 6, 2023Immunology

MondoA Drives Malignancy in cALL through Enhanced Adaptation to Metabolic Stress

A. Sipol, E. Hameister, B. Xue, A. Petry, C. Prexler, M. Barenboim, R. A. Rubio, M. C. Baldauf, D. G. Franchina, J. Schmaeh, G. Richter, G. Cario, T. G. P. Gruenewald, A. Goerlach, D. Brenner, , S. E. G. Burdach

This study shows MondoA promotes malignancy in pediatric cALL by enhancing metabolic stress adaptation, with potential therapeutic implications.

bioRxiv · Nov 1, 2020Cancer Biology

PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis

E. Danileviciute, N. Zeng, C. Capelle, N. Paczia, M. A. Gillespie, H. Kurniawan, D. Coowar, D. Vogt-Weisenhorn, G. Gomez-Giro, M. Grusdat, A. Baron, C. Guerin, D. G. Franchina, C. Leonard, O. Domingues, , F. Q. He

This study shows PARK7/DJ-1 enhances PDH activity in Tregs by inhibiting PDHA phosphorylation, maintaining Treg homeostasis and reducing EAE severity.

bioRxiv · Dec 20, 2019Biochemistry