Author

R. E. Lewis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Cell Biology· 1

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Research Focus:cancer & tumor microenvironment· 6 Organism:human· 6 Approach:experimental assay· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

K. W. Fisher· 6 shared R. A. Svoboda· 6 shared C. Rao· 5 shared D. Chatterjee· 4 shared D. H. Huisman· 4 shared H. M. Vieira· 4 shared D. E. Frodyma· 3 shared J. W. Askew· 3 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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6 shared papersCancer Biology

K. W. Fisher

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

KSR1 mediates small-cell lung carcinoma tumor initiation and cisplatin resistance

D. Chatterjee, R. A. Svoboda, D. H. Huisman, B. J. Drapkin, H. M. Vieira, C. Rao, J. W. Askew, K. W. Fisher, R. E. Lewis

This study identifies KSR1 as a critical regulator of SCLC tumor initiation and cisplatin resistance, showing that its disruption enhances cisplatin toxicity and reduces tumor-initiating cells.

bioRxiv · Feb 23, 2024Cancer Biology

SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status

B. Daley, H. M. Vieira, C. Rao, J. M. Hughes, Z. M. Beckley, D. H. Huisman, D. Chatterjee, N. E. Sealover, K. Cox, J. W. Askew, R. A. Svoboda, K. W. Fisher, R. E. Lewis, R. L. Kortum

This study shows that targeting SOS1 or KSR1 enhances MEK inhibitor efficacy and prevents resistance in KRAS-mutated cancers, depending on specific KRAS and co-mutation status.

bioRxiv · Dec 6, 2022Cancer Biology

PGC-1β and ERRα promote glutamine metabolism and colorectal cancer survival via transcriptional regulation of PCK2

D. E. Frodyma, T. C. Troia, J. A. Berg, C. Rao, R. A. Svoboda, D. D. Shinde, V. C. Thomas, R. E. Lewis, K. W. Fisher

This study identifies PCK2 as a target of PGC-1β and ERRα that promotes glutamine metabolism and colorectal cancer survival through transcriptional regulation.

bioRxiv · May 20, 2022 · PreprintCancer Biology

Post-transcriptional control of SRSF9 promotes the epithelial-to-mesenchymal transition (EMT) in colorectal cancer cells

C. Rao, R. A. Svoboda, S. Southekal, H. M. Vieira, D. H. Huisman, D. Chatterjee, C. Guda, K. W. Fisher, O. Anczukow, R. E. Lewis

The paper shows that KSR1-dependent signaling in CRC cells promotes SRSF9-mediated splicing of EPSTI1 mRNA, which drives EMT and metastasis.

bioRxiv · May 16, 2022 · PreprintCell Biology

KSR2 promotes self-renewal and clonogenicity of small-cell lung carcinoma

D. H. Huisman, D. Chatterjee, R. A. Svoboda, H. M. Vieira, A. S. Ireland, S. Skupa, J. W. Askew, D. E. Frodyma, L. Girard, K. W. Fisher, M. Kareta, J. Minna, T. G. Oliver, R. E. Lewis

This study shows KSR2 promotes self-renewal and clonogenicity in ASCL1-subtype SCLC by enhancing ERK signaling and tumor initiating capacity.

bioRxiv · Feb 11, 2022Cancer Biology

KSR1-and ERK-dependent Translational Regulation of the Epithelial-to-Mesenchymal Transition

C. Rao, D. E. Frodyma, S. Southekal, R. A. Svoboda, A. R. Black, C. Guda, T. Mizutani, H. Clever, K. R. Johnson, K. W. Fisher, R. E. Lewis

This study shows KSR1 and ERK promote EMT by selectively translating EPSTI1, which facilitates the E-to N-cadherin switch and enhances migration and invasion in CRC cells.

bioRxiv · Jan 18, 2021Cancer Biology