Author

J. Misasi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Research Focus:protein structure prediction· 2 Organism:virus· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

P. D. Kwong· 6 shared T. Zhou· 5 shared I.-T. Teng· 4 shared J. R. Mascola· 4 shared L. Wang· 4 shared W. Shi· 4 shared Y. Zhang· 4 shared A. Pegu· 3 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

P. D. Kwong

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A multispecific antibody prevents immune escape and confers pan-SARS-CoV-2 neutralization

J. Misasi, R. R. Wei, L. Wang, A. Pegu, C.-J. Wei, O. Oloniniyi, T. Zhou, J. I. Moliva, B. Zhao, M. Choe, E. S. Yang, Y. Zhang, M. Boruszczak, M. Chen, K. Leung, , N. J. Sullivan

This paper develops multispecific antibodies that neutralize all SARS-CoV-2 variants, including Omicron, by targeting multiple epitopes on the spike protein.

bioRxiv · Jul 29, 2022 · PreprintImmunology

Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones

N. S. Lima, M. Musayev, T. S. Johnston, D. A. Wagner, A. R. Henry, L. Wang, E. S. Yang, Y. Zhang, K. Birungi, W. P. Black, S. O'Dell, S. D. Schmidt, D. Moon, C. G. Lorang, B. Zhao, , P. D. Kwong

The paper examines antibody responses to SARS-CoV-2 variants, finding convergent epitope specificities, V gene usage, and public B cell clones across different variants.

bioRxiv · Mar 28, 2022Immunology

Molecular probes of spike ectodomain and its subdomains for SARS-CoV-2 variants, Alpha through Omicron

I.-T. Teng, A. F. Nazzari, M. Choe, T. Liu, M. Oliveira de Souza, Y. Petrova, Y. Tsybovsky, S. Wang, B. Zhang, M. Artamonov, B. Madan, A. Huang, S. N. Lopez Acevedo, X. Pan, T. J. Ruckwardt, , P. D. Kwong

The paper designs and produces molecular probes for SARS-CoV-2 variants to assess immune responses and isolate neutralizing antibodies.

bioRxiv · Dec 29, 2021 · PreprintImmunology

Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529

T. Zhou, L. Wang, J. Misasi, A. Pegu, Y. Zhang, D. R. Harris, A. S. Olia, C. A. Talana, E. S. Yang, M. Chen, M. Choe, W. Shi, I.-T. Teng, A. Creanga, C. Jenkins, , P. D. Kwong

The paper identifies potent monoclonal antibodies that neutralize the B.1.1.529 SARS-CoV-2 variant and reveals structural mechanisms enabling their effectiveness.

bioRxiv · Dec 27, 2021Immunology

High-Throughput, Single-Copy Sequencing Reveals SARS-CoV-2 Spike Variants Coincident with Mounting Humoral Immunity during Acute COVID-19

S. H. Ko, E. Bayat Mokhtari, P. Mudvari, S. Stein, C. D. Stringham, D. Wagner, S. Ramelli, M. J. Ramirez-Benitez, J. R. Strich, R. T. Davey, T. Zhou, J. Misasi, P. D. Kwong, D. S. Chertow, N. J. Sullivan, E. A. Boritz

This study uses high-throughput single-copy sequencing to detect SARS-CoV-2 spike variants during acute COVID-19, revealing genetic adaptation coinciding with humoral immunity.

bioRxiv · Feb 21, 2021Microbiology

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

T. Zhou, I.-T. Teng, A. S. Olia, G. Cerutti, J. Gorman, A. Nazzari, W. Shi, Y. Tsybovsky, L. Wang, S. Wang, B. Zhang, Y. Zhang, P. S. Katsamba, Y. Petrova, B. B. Banach, , P. D. Kwong

The paper develops biotin-labeled SARS-CoV-2 spike molecular probes using structure-based design and purification methods, achieving high yields and enabling antibody characterization.

bioRxiv · Jun 22, 2020Immunology