Author

M. Choe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 9 Biochemistry· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Research Focus:host-pathogen & immune response· 7 Assay:proteomics· 6 Research Focus:drug response / drug discovery· 5 Organism:human· 5 Research Focus:cell type annotation· 4 Organism:non-human primate· 4 Organism:mouse· 3

Frequent Co-Authors

M. G. Joyce· 5 shared R. S. Sankhala· 5 shared A. Hajduczki· 4 shared J. R. Mascola· 4 shared L. Wang· 4 shared P. D. Kwong· 4 shared T. Zhou· 4 shared W. Shi· 4 shared

Activity by Year

2020-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersImmunology

M. G. Joyce

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

Convergent Sequence Features of Antiviral B Cells

A. A. Abu-Shmais, M. J. Vukovich, P. T. Wasdin, Y. P. Suresh, S. A. Rush, R. A. Gillespie, R. S. Sankhala, M. Choe, M. G. Joyce, M. Kanekiyo, J. S. McLellan, I. S. Georgiev

The paper maps antibody sequences to antigen specificity across multiple viral antigens, identifying convergent sequence features in antiviral B cells.

mBio · Oct 16, 2024Peer-reviewedImmunology

Genetically encoded tool for manipulation of Δ{Psi}m identifies the latter as the driver of integrative stress response induced by ATP Synthase dysfunction

M. Choe, D. V. Titov

The paper develops a genetically encoded tool to manipulate mitochondrial membrane potential and shows it drives the integrated stress response from ATP synthase dysfunction.

bioRxiv · Dec 27, 2023Biochemistry

A multispecific antibody prevents immune escape and confers pan-SARS-CoV-2 neutralization

J. Misasi, R. R. Wei, L. Wang, A. Pegu, C.-J. Wei, O. Oloniniyi, T. Zhou, J. I. Moliva, B. Zhao, M. Choe, E. S. Yang, Y. Zhang, M. Boruszczak, M. Chen, K. Leung, , N. J. Sullivan

This paper develops multispecific antibodies that neutralize all SARS-CoV-2 variants, including Omicron, by targeting multiple epitopes on the spike protein.

bioRxiv · Jul 29, 2022 · PreprintImmunology

A SARS-CoV-2 Spike Ferritin Nanoparticle Vaccine is Protective and Promotes a Strong Immunological Response in the Cynomolgus Macaque Coronavirus Disease 2019 (COVID-19) Model

S. C. Johnston, K. M. Ricks, I. Lakhal-Naouar, A. Jay, C. Subra, J. L. Raymond, H. A. D. King, F. Rossi, T. L. Clements, D. Fetterer, S. Tostenson, C. M. Cincotta, H. R. Hack, C. Kuklis, S. Soman, , A Nalca

This study evaluates a SARS-CoV-2 Spike ferritin nanoparticle vaccine in cynomolgus macaques, showing strong immunological responses and protection against infection.

bioRxiv · Mar 25, 2022Microbiology

Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability

W. Shi, L. Wang, T. Zhou, M. Sastry, E. S. Yang, Y. Zhang, M. Chen, X. Chen, M. Choe, A. Creanga, K. Leung, A. S. Olia, A. Pegu, R. Rawi, C.-H. Shen, , P. D. Kwong

This paper identifies an antibody, WS6, from a mouse immunized with SARS-CoV-2 spike mRNA, which neutralizes diverse beta-coronaviruses by targeting a conserved helical epitope on the S2 subunit.

bioRxiv · Jan 25, 2022Immunology

Molecular probes of spike ectodomain and its subdomains for SARS-CoV-2 variants, Alpha through Omicron

I.-T. Teng, A. F. Nazzari, M. Choe, T. Liu, M. Oliveira de Souza, Y. Petrova, Y. Tsybovsky, S. Wang, B. Zhang, M. Artamonov, B. Madan, A. Huang, S. N. Lopez Acevedo, X. Pan, T. J. Ruckwardt, , P. D. Kwong

The paper designs and produces molecular probes for SARS-CoV-2 variants to assess immune responses and isolate neutralizing antibodies.

bioRxiv · Dec 29, 2021 · PreprintImmunology

Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529

T. Zhou, L. Wang, J. Misasi, A. Pegu, Y. Zhang, D. R. Harris, A. S. Olia, C. A. Talana, E. S. Yang, M. Chen, M. Choe, W. Shi, I.-T. Teng, A. Creanga, C. Jenkins, , P. D. Kwong

The paper identifies potent monoclonal antibodies that neutralize the B.1.1.529 SARS-CoV-2 variant and reveals structural mechanisms enabling their effectiveness.

bioRxiv · Dec 27, 2021Immunology

Protection against SARS-CoV-2 Beta Variant in mRNA-1273 Boosted Nonhuman Primates

K. S. Corbett, M. Gagne, D. Wagner, S. O'Connell, S. R. Narpala, D. R. Flebbe, S. F. Andrew, R. L. Davis, B. Flynn, T. S. Johnston, C. Stringham, L. Lai, D. Valentin, A. Van Ry, Z. Flinchbaugh, , A Pekosz

mRNA-1273 boosted nonhuman primates show increased neutralizing antibody responses and protection against SARS-CoV-2 beta variant infection.

bioRxiv · Aug 11, 2021 · PreprintImmunology

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

H. A. D. King, M. G. Joyce, I. Elakhal Naouar, A. Ahmed, C. Macedo Cincotta, C. Subra, K. K. Peachman, H. H. Hack, R. E. Chen, P. V. Thomas, W.-H. Chen, R. S. Sankhala, A. Hajduczki, E. J. Martinez, C. E. Peterson, , L. L Jagodzinski

This study evaluates an adjuvanted SARS-CoV-2 RBD nanoparticle vaccine in macaques, showing robust immune responses and protection against viral challenge and variants.

bioRxiv · Apr 9, 2021Immunology

Efficacy of a Broadly Neutralizing SARS-CoV-2 Ferritin Nanoparticle Vaccine in Nonhuman Primates

M. G. Joyce, H. A. D. King, I. Elakhal Naouar, A. Ahmed, K. K. Peachman, C. M. Cincotta, C. Subra, R. E. Chen, P. V. Thomas, W.-H. Chen, R. S. Sankhala, A. Hajduczki, E. J. Martinez, C. E. Peterson, W. C. Chang, , N. Karasavva

A SARS-CoV-2 Spike ferritin nanoparticle vaccine induces broad neutralizing antibodies and protects nonhuman primates against respiratory infection and disease.

bioRxiv · Mar 24, 2021 · PreprintImmunology

A Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein

M. G. Joyce, R. S. Sankhala, W.-H. Chen, M. Choe, H. Bai, A. Hajduczki, L. Yan, S. L. Sterling, C. Peterson, E. C. Green, C. Smith, N. de Val, M. Amare, P. Scott, E. D. Laing, , K. Modjarrad

The paper reports the high-resolution structure of the SARS-CoV-2 Spike RBD and identifies a conserved epitope accessible in open conformations, which is targeted by cross-reactive antibodies.

bioRxiv · Mar 15, 2020 · PreprintImmunology

Quantitative single cell heterogeneity profiling of patient derived tumor initiating gliomaspheres reveals unique signatures of malignancy and response

M. Masterman-Smith, N. A. Graham, E. Panosyan, J. Mottahedeh, E. E. Samuels, A. Nunez, S. H. Lim, T. Phillips, M. Choe, K. Visnyei, W. H. Yong, T. G. Graeber, M.-F. Lang, H. Kornblum, J. Sun

The paper uses single cell proteomic analysis to identify distinct signaling phenotypes in gliomaspheres, revealing EGFR and AKT/TORC1 signaling divergence and potential therapeutic targets.

bioRxiv · Jan 14, 2020 · PreprintCancer Biology