Author

J. N. Lakins

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

E. S. Hwang· 2 shared V. M. Weaver· 2 shared A. C. Nelson· 1 shared A. Chauhan· 1 shared A. J. Ironside· 1 shared A. Nasir· 1 shared A. P. Drain· 1 shared A. S. Barrett· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

E. S. Hwang

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2 papers

Recent·Most cited

Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer progression

J. J. Northey, Y. Yui, M.-K. Hayward, C. Stashko, F. Kai, J. K. Mouw, D. Thakar, J. N. Lakins, A. J. Ironside, S. Samson, R. A. Mukhtar, E. S. Hwang, V. M. Weaver

The paper shows that stiff extracellular matrix and integrin mechanosignaling increase mammary stem-progenitor cells, promoting breast cancer risk and progression through RANK signaling.

bioRxiv · Apr 19, 2022 · PreprintCancer Biology

Inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stromal stiffening

O. Maller, A. P. Drain, A. S. Barrett, S. Borgquist, B. Ruffell, P. T. Thanh, T. Gruosso, H. Kuasne, J. N. Lakins, I. Acerbi, J. M. Barnes, T. Nemkov, A. Chauhan, J. Gruenberg, A. Nasir, , V. M. Weaver

This study shows that inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stiffening, identifying lysyl hydroxylase two as a biomarker.

bioRxiv · Feb 13, 2020Cancer Biology