E. S. Hwang

Single Cell Expression Analysis of Ductal Carcinoma in Situ Identifies Alterations in Epithelial Integrity

This study uses scRNA-seq to analyze DCIS and normal breast tissue, identifying clonal heterogeneity and cell state changes associated with progression to invasive cancer.

Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome.

The paper analyzes molecular differences in ductal carcinoma in situ (DCIS) by self-reported race and outcome groups, identifying variations in gene expression, tumor microenvironment, and copy number variations between Black and White women.

Confocal reflectance microscopy for mapping collagen fiber organization in the vitreous gel of the eye

This study uses confocal reflectance microscopy to map collagen fiber organization in porcine vitreous, revealing fiber density variations and poor alignment.

Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer progression

The paper shows that stiff extracellular matrix and integrin mechanosignaling increase mammary stem-progenitor cells, promoting breast cancer risk and progression through RANK signaling.

Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma

The paper analyzes tumor microenvironment changes from normal to invasive breast cancer using imaging and machine learning, finding coordinated shifts in stromal cell location and function.

Inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stromal stiffening

This study shows that inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stiffening, identifying lysyl hydroxylase two as a biomarker.

Minimal Barriers to Invasion During Human Colorectal Tumor Growth

The paper examines intra-tumoral heterogeneity in colorectal tumors and finds that early multiclonal invasion occurs with minimal barriers to invasion.