Author

J. Gruenberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. Vossio· 3 shared C. C. Scott· 2 shared D. Moreau· 2 shared F. Vacca· 2 shared J. Paz Montoya· 2 shared M. Moniatte· 2 shared V. Mercier· 2 shared A. C. Nelson· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCell Biology

S. Vossio

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stromal stiffening

O. Maller, A. P. Drain, A. S. Barrett, S. Borgquist, B. Ruffell, P. T. Thanh, T. Gruosso, H. Kuasne, J. N. Lakins, I. Acerbi, J. M. Barnes, T. Nemkov, A. Chauhan, J. Gruenberg, A. Nasir, , V. M. Weaver

This study shows that inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stiffening, identifying lysyl hydroxylase two as a biomarker.

bioRxiv · Feb 13, 2020Cancer Biology

ENDOSOMAL MEMBRANE TENSION REGULATES ESCRT-III-DEPENDENT INTRA-LUMENAL VESICLE FORMATION

V. Mercier, J. Larios, G. Molinard, A. Goujon, S. Matile, J. Gruenberg, A. Roux

The paper shows that reduced endosomal membrane tension facilitates ESCRT-III polymerization and increases intra-lumenal vesicle formation.

bioRxiv · May 23, 2019Cell Biology

Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice

D. Moreau, F. Vacca, S. Vossio, C. C. Scott, A. Colaco, J. Paz Montoya, C. Ferguson, M. Damme, M. Moniatte, R. G. Parton, F. M. Platt, J. Gruenberg

The paper identifies thioperamide as a drug that increases lysobisphosphatidic acid (LBPA) levels, reducing cholesterol overload in Niemann-Pick type C cells and mice.

bioRxiv · Mar 8, 2019Cell Biology

Cyclodextrin triggers MCOLN1-dependent endo-lysosome secretion in Niemann-Pick type C cells

F. Vacca, S. Vossio, V. Mercier, D. Moreau, S. Johnson, J. Paz Montoya, M. Moniatte, J. Gruenberg

This study shows cyclodextrin induces endo-lysosome secretion in Niemann-Pick type C cells via MCOLN1, reducing cholesterol storage.

bioRxiv · Aug 27, 2018Cell Biology

TFAP2 transcription factors are regulators of lipid droplet biogenesis

C. C. Scott, S. Vossio, J. Rougemont, J. Gruenberg

The paper identifies TFAP2 transcription factors as regulators of lipid droplet biogenesis, showing they mediate the Wnt3a-induced signal instead of canonical TCF/LEF factors.

bioRxiv · Mar 14, 2018Cell Biology