Author

H. Kuasne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

M. Park· 3 shared J.-F. Cote· 2 shared A. C. Nelson· 1 shared A. Chauhan· 1 shared A. Fortier· 1 shared A. Malina· 1 shared A. Marechal· 1 shared A. Nasir· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersCancer Biology

M. Park

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5 papers

Recent·Most cited

Targeting the dependence on PIK3C3-mTORC1 signaling in dormancy-prone breast cancer cells blunts metastasis initiation

I. E. Elkholi, A. Robert, C. Malouf, H. Kuasne, S. Drapela, G. Macleod, S. Hebert, A. Pacis, V. Calderon, C. L. Kleinman, A. P. Gomes, J. A. Aguirre-Ghiso, M. Park, S. Angers, J.-F. Cote

This study identifies Pik3c3 as a vulnerability in dormancy-prone breast cancer cells, showing its inhibition reduces metastasis in preclinical models.

bioRxiv · Aug 2, 2023Cancer Biology

The G protein-coupled receptor TBXA2R activates ERMs to control cell motility and invasion of triple-negative breast cancer cells.

K. Leguay, O. Naffati, Y. Y. He, M. Rogue, C. Tesniere, M. Gombos, H. Kuasne, L. Gaboury, C. Le Gouill, S. Meloche, M. Bouvier, S. Carreno

bioRxiv · Mar 28, 2023 · PreprintCancer Biology

Inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stromal stiffening

O. Maller, A. P. Drain, A. S. Barrett, S. Borgquist, B. Ruffell, P. T. Thanh, T. Gruosso, H. Kuasne, J. N. Lakins, I. Acerbi, J. M. Barnes, T. Nemkov, A. Chauhan, J. Gruenberg, A. Nasir, , V. M. Weaver

This study shows that inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stiffening, identifying lysyl hydroxylase two as a biomarker.

bioRxiv · Feb 13, 2020Cancer Biology

GLUT1 inhibition blocks growth of RB1-positive Triple Negative Breast Cancer

Q. Wu, W. Alawi, G. Deblois, J. Cruickshank, S. Duan, E. L. Fernandes, J. Haight, S. A. Tonekaboni, A. Fortier, H. Kuasne, T. McKee, H. Mahmoud, S. Cameron, N. D. Artun, W. Chen, , C. H. Arrowsmith

This study shows that GLUT1 inhibition reduces growth of RB1-positive TNBC cells with high glycolytic activity and low OXPHOS, suggesting a therapeutic target in this subset.

bioRxiv · Sep 11, 2019Cancer Biology

FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.

A. Orthwein, S. Findlay, J. Heath, V. Luo, A. Malina, Z. Li, A. Samiei, E. S. Cheyou, M. Karam, H. Bagci, D. Rahat, D. Grapton, E. G. Lavoie, C. Dove, H. Khaled, , H. Kuasne

This study identifies FAM35A as a novel REV7 effector that promotes NHEJ and restricts HR by limiting DNA end resection at DSBs.

bioRxiv · Jul 11, 2018Cancer Biology