Author

J. J. Northey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

V. M. Weaver· 3 shared C. Stashko· 2 shared F. Kai· 2 shared A. F. Long· 1 shared A. J. Ironside· 1 shared A. Kuo· 1 shared A. M. Leidal· 1 shared A. P. Wiita· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiochemistry

V. M. Weaver

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Design of a mucin-selective protease for targeted degradation of cancer-associated mucins

K. Pedram, D. J. Shon, G. S. Tender, N. R. Mantuano, J. J. Northey, K. J. Metcalf, S. P. Wisnovsky, N. M. Riley, G. C. Forcina, S. A. Malaker, A. Kuo, B. M. George, C. L. Miller, K. M. Casey, J. G. Vilches-Moure, , C. R. Bertozzi

This paper designs a mucin-selective protease conjugated to a nanobody to degrade cancer-associated mucins, showing reduced tumor growth in mouse models.

bioRxiv · May 20, 2022Biochemistry

Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer progression

J. J. Northey, Y. Yui, M.-K. Hayward, C. Stashko, F. Kai, J. K. Mouw, D. Thakar, J. N. Lakins, A. J. Ironside, S. Samson, R. A. Mukhtar, E. S. Hwang, V. M. Weaver

The paper shows that stiff extracellular matrix and integrin mechanosignaling increase mammary stem-progenitor cells, promoting breast cancer risk and progression through RANK signaling.

bioRxiv · Apr 19, 2022 · PreprintCancer Biology

ECM dimensionality tunes actin tension to modulate the endoplasmic reticulum and spheroid phenotype

F. Kai, G. Ou, R. W. Tourdot, C. Stashko, G. Gaietta, M. F. Swift, N. Volkmann, A. F. Long, Y. Han, H. H. Huang, J. J. Northey, A. M. Leidal, V. Viasnoff, D. M. Bryant, W. Guo, , V. M. Weaver

The paper shows that ECM dimensionality affects actin tension, which in turn modulates endoplasmic reticulum function and spheroid resilience in mammary epithelial cells.

bioRxiv · Jul 14, 2021 · PreprintCell Biology