A. C. Nelson

Unleashing the secrets of plant-fungal interactions using a transformation-free confocal staining technique that supports AI-assisted quantitative analysis

This paper introduces a transformation-free confocal staining technique for visualizing plant-fungal interactions and uses machine learning to quantify fungal volume and nuclear breakdown.

Clinical Significance of the Stromatic Component in Ovarian Cancer: Quantity Over Quality in Outcome Prediction

This study shows that higher tumor-stroma proportion (TSP) in ovarian cancer is linked to worse patient outcomes, including shorter progression-free and overall survival, and increased chemoresistance.

Fecal Microbiota Restoration Modulates the Microbiome in Inflammation-Driven Colorectal Cancer

The paper examines microbiome changes in inflammation-driven colorectal cancer using a mouse model, finding increased Akkermansia in microbiome-restored mice and elevated lipocalin-2 in unrestored animals.

Receptor for Hyaluronan-Mediated Motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients.

This study identifies RHAMM as a marker of invasive niches in breast cancer, showing its association with poor outcomes and promoting invasion through a 27-gene signature.

Multi-omic analysis of subtype evolution and heterogeneity in high-grade serous ovarian carcinoma

This paper investigates the evolution and heterogeneity of high-grade serous ovarian carcinoma using multi-omic analysis, finding that subtypes emerge later in tumor development and are not discrete but rather part of a continuous spectrum.

Analytical Validation of a COVID-19 qRT-PCR Detection Assay Using a 384-well Format and Three Extraction Methods

This study validates a qRT-PCR assay for SARS-CoV-2 detection using a 384-well format and three extraction methods, showing robust accuracy and sensitivity with commercial reagents.

Inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stromal stiffening

This study shows that inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stiffening, identifying lysyl hydroxylase two as a biomarker.

Transitions in paternal dominance regulate offspring growth and metabolic transcription

The paper shows that paternal social status in mice reversibly affects offspring growth and liver transcription through non-genetic cues, modulated by maternal experience.