Author

R. E. Simmonds

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

B. S. Hall· 2 shared A. Cavalie· 1 shared F. J. Salguero· 1 shared I. Gamayun· 1 shared J. Diaz Delgado· 1 shared J. Newcombe· 1 shared J. Ogbechi· 1 shared L. T.-H. Hsieh· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

B. S. Hall

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Author profile →

2 papers

Recent·Most cited

Mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans infection

L. T.-H. Hsieh, B. S. Hall, J. Newcombe, T. A. Mendum, S. Santana-Varela, Y. Umrania, M. J. Deery, W. Q. Shi, J. Diaz Delgado, F. J. Salguero, R. E. Simmonds

This study shows mycolactone causes endothelial glycocalyx and basement membrane loss via Sec61-dependent mechanisms, leading to vascular dysfunction and tissue necrosis in Buruli ulcer.

bioRxiv · Feb 21, 2023Microbiology

Mycolactone enhances the Ca2+ leakage from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state

P. Bhadra, S. Dos Santos, I. Gamayun, T. Pick, J. Ogbechi, B. S. Hall, R. Zimmermann, V. Helms, R. E. Simmonds, A. Cavalie

This study shows mycolactone enhances Ca2+ leakage from the ER by trapping Sec61 translocons in a Ca2+ permeable state, leading to ER Ca2+ depletion.

bioRxiv · May 12, 2021Biochemistry