Organoid-derived Duodenum Intestine-Chip for preclinical drug assessment in a human relevant system
M. Kasendra, R. Luc, J. Yin, D. V. Manatakis, A. Apostolou, L. Sunuwar, J. Obrigewitch, G. A. Hamilton, M. Donowitz, K. Karalis
The paper develops a human Duodenum Intestine-Chip model to better predict drug metabolism and drug-drug interactions by emulating intestinal functions and CYP450 induction.
bioRxiv · Aug 5, 2019Cell Biology