Author

D. V. Manatakis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Research Focus:drug response / drug discovery· 5 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:organoid / primary culture· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

K. Karalis· 6 shared G. A. Hamilton· 4 shared E. S. Manolakos· 3 shared A. Apostolou· 2 shared C. D. Hinojosa· 2 shared G. Hamilton· 2 shared I. Pediaditakis· 2 shared K. R. Kodella· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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6 shared papersBioengineering

K. Karalis

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Assessment of Human Renal Transporter Based Drug-Drug Interactions Using Proximal Tubule Kidney-Chip

A. R. Nookala, J. Ronxhi, J. Sliz, S. Jeanty, D. V. Manatakis, S. Jadalannagari, G. Hamilton, H. Park, Y. He, M. Lavarias, G. Luo, K. Jang, D. McKenzie

This study develops a human Proximal Tubule Kidney-Chip to assess renal transporter-based drug-drug interactions and demonstrates its ability to predict clinical outcomes and clearance values.

bioRxiv · May 12, 2022 · PreprintCell Biology

A Microengineered Brain-Chip to Model Neuroinflammation in Humans

I. Pediaditakis, K. R. Kodella, D. V. Manatakis, C. Y. Le, S. Barthakur, A. Sorets, A. Gravanis, L. Ewart, L. L. Rubin, E. S. Manolakos, C. D. Hinojosa, K. Karalis

The paper presents a human Brain-Chip that models neuroinflammation by recapitulating brain cell interactions and BBB function, showing improved complexity and clinical relevance compared to existing models.

bioRxiv · Mar 11, 2022Bioengineering

Human immunocompetent Organs-on-Chips platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

L. Cabon, D. Petropolis, W. Tien-Street, P. R. Ng, H. S. Grant, K. Karalis, G. A. Hamilton, J. Sam, T. Weinzierl, T. Fauti, A. Freimoser-Grundschober, J. Eckmann, C. Hage, M. Geiger, V. Micallef, , R. Barrile

The paper demonstrates that human immunocompetent Organs-on-Chips can predict safety liabilities of T-cell bispecific antibodies targeting tumor antigens.

bioRxiv · Feb 22, 2021Cancer Biology

A Micro-engineered Human Colon Intestine-Chip Platform to Study Leaky Barrier

A. Apostolou, R. Panchakshari, A. Banerjee, D. V. Manatakis, M. D. Paraskevopoulou, R. Luc, G. Abu Ali, A. Dimitriou, C. Lucchesi, G. Kulkarni, T. I. Maulana, B. Bleck, E. S. Manolakos, G. A. Hamilton, C. Giallourakis, K. Karalis

This paper introduces a Colon Intestine-Chip platform to study leaky gut by combining organoids and Organ-on-Chip technologies, showing its response to inflammatory cytokines and IL-22.

bioRxiv · Aug 28, 2020 · PreprintBioengineering

Modeling Alpha-Synuclein Pathology in a Human Brain-Chip to Assess Blood-Brain Barrier Disruption in Parkinson's Disease

I. Pediaditakis, K. R. Kodella, D. V. Manatakis, C. D. Hinojosa, E. S. Manolakos, L. L. Rubin, G. A. Hamilton, K. Karalis

The paper develops a human Brain-Chip model of Parkinson's disease to study blood-brain barrier disruption and synucleinopathy mechanisms.

bioRxiv · Jul 22, 2020Bioengineering

Modeling alcoholic liver disease in a human Liver-Chip

J. C. Nawroth, D. B. Petropolis, D. V. Manatakis, T. I. Maulana, G. Burchett, K. Schluender, A. Witt, A. Shukla, G. Hamilton, E. Seki, S. Lu, K. Karalis

This paper develops a human ALD Liver-Chip to model alcohol-induced liver injury, showing it recapitulates FLD markers and enables multimodal profiling of clinically relevant endpoints.

bioRxiv · Jul 14, 2020 · PreprintBioengineering

Organoid-derived Duodenum Intestine-Chip for preclinical drug assessment in a human relevant system

M. Kasendra, R. Luc, J. Yin, D. V. Manatakis, A. Apostolou, L. Sunuwar, J. Obrigewitch, G. A. Hamilton, M. Donowitz, K. Karalis

The paper develops a human Duodenum Intestine-Chip model to better predict drug metabolism and drug-drug interactions by emulating intestinal functions and CYP450 induction.

bioRxiv · Aug 5, 2019Cell Biology