K. Karalis

A Microengineered Brain-Chip to Model Neuroinflammation in Humans

The paper presents a human Brain-Chip that models neuroinflammation by recapitulating brain cell interactions and BBB function, showing improved complexity and clinical relevance compared to existing models.

Human immunocompetent Organs-on-Chips platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

The paper demonstrates that human immunocompetent Organs-on-Chips can predict safety liabilities of T-cell bispecific antibodies targeting tumor antigens.

A lung-on-chip model reveals an essential role for alveolar epithelial cells in controlling bacterial growth in early tuberculosis

This study uses a lung-on-chip model to show that alveolar epithelial cell-derived surfactant limits early Mycobacterium tuberculosis growth by removing virulence factors.

A Micro-engineered Human Colon Intestine-Chip Platform to Study Leaky Barrier

This paper introduces a Colon Intestine-Chip platform to study leaky gut by combining organoids and Organ-on-Chip technologies, showing its response to inflammatory cytokines and IL-22.

Modeling Alpha-Synuclein Pathology in a Human Brain-Chip to Assess Blood-Brain Barrier Disruption in Parkinson's Disease

The paper develops a human Brain-Chip model of Parkinson's disease to study blood-brain barrier disruption and synucleinopathy mechanisms.

Modeling alcoholic liver disease in a human Liver-Chip

This paper develops a human ALD Liver-Chip to model alcohol-induced liver injury, showing it recapitulates FLD markers and enables multimodal profiling of clinically relevant endpoints.

A Micro-Engineered Airway Lung-Chip Models Key Features of Viral-Induced Exacerbation of Asthma

This paper develops a micro-engineered Airway Lung-Chip model that replicates viral-induced asthma exacerbation features and evaluates immunomodulatory therapies.

Mechanical Stimuli Affect E. coli Heat Stable Enterotoxin-cyclic GMP Signaling in a Human Enteroid Intestine-Chip Diarrhea Model

This study shows that fluid flow in an Intestine-Chip model alters intestinal epithelial responses to E. coli heat-stable enterotoxin, increasing cGMP secretion without enhancing intracellular cGMP.

Organoid-derived Duodenum Intestine-Chip for preclinical drug assessment in a human relevant system

The paper develops a human Duodenum Intestine-Chip model to better predict drug metabolism and drug-drug interactions by emulating intestinal functions and CYP450 induction.

Liver-Chip: Reproducing Human and Cross-Species Toxicities

The paper designs Liver-Chips for rat, dog, and human to replicate species-specific liver toxicities and predict human relevance.