Author

M. Kasendra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Sontheimer-Phelps· 2 shared A. Tovaglieri· 2 shared C. A. Richmond· 2 shared D. B. Chou· 2 shared D. E. Ingber· 2 shared D. T. Breault· 2 shared J. Yin· 2 shared k. karalis· 2 shared

Activity by Year

2019-2019 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

A. Sontheimer-Phelps

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Author profile →

4 papers

Recent·Most cited

Mechanical Stimuli Affect E. coli Heat Stable Enterotoxin-cyclic GMP Signaling in a Human Enteroid Intestine-Chip Diarrhea Model

l. sunuwar, J. Yin, m. Kasendra, k. karalis, J. Kaper, J. M. Fleckenstein, M. Donowitz

This study shows that fluid flow in an Intestine-Chip model alters intestinal epithelial responses to E. coli heat-stable enterotoxin, increasing cGMP secretion without enhancing intracellular cGMP.

bioRxiv · Sep 18, 2019Microbiology

Human colon-on-a-chip enables continuous in vitro analysis of colon mucus layer accumulation and physiology

A. Sontheimer-Phelps, D. B. Chou, A. Tovaglieri, T. C. Ferrante, T. Duckworth, C. Fadel, V. Frismantas, S. Jalili Firoozinezhad, M. Kasendra, E. Stas, J. C. Weaver, C. A. Richmond, O. Levy, R. Prantil-Baun, D. T. Breault, D. E. Ingber

This study develops a human colon-on-a-chip model that replicates the mucus bilayer structure and function, enabling real-time non-invasive analysis of mucus layer dynamics.

bioRxiv · Aug 20, 2019Cell Biology

Organoid-derived Duodenum Intestine-Chip for preclinical drug assessment in a human relevant system

M. Kasendra, R. Luc, J. Yin, D. V. Manatakis, A. Apostolou, L. Sunuwar, J. Obrigewitch, G. A. Hamilton, M. Donowitz, K. Karalis

The paper develops a human Duodenum Intestine-Chip model to better predict drug metabolism and drug-drug interactions by emulating intestinal functions and CYP450 induction.

bioRxiv · Aug 5, 2019Cell Biology

Species-specific enhancement of enterohemorrhagic E. Coli pathogenesis mediated by microbiome metabolites

A. Tovaglieri, A. Sontheimer-Phelps, A. Geirnaert, R. Prantil-Baun, D. M. Camacho, D. B. Chou, S. Jalili-Firoozinezhad, T. de Wouters, M. Kasendra, M. Super, M. Cartwright, C. A. Richmond, D. T. Breault, C. Lacroix, D. E. Ingber

The paper identifies human gut microbiome metabolites that enhance EHEC pathogenesis in a human colonic organ chip model, contributing to species-specific susceptibility.

bioRxiv · Jan 7, 2019Bioengineering