G. A. Hamilton

Age and obesity-driven changes in the extracellular matrix of the primary tumor and metastatic site influence tumor invasion and metastatic outgrowth

This study shows that age and obesity alter the extracellular matrix (ECM) in primary tumors and metastatic sites, promoting tumor invasion and metastasis in triple-negative breast cancer.

Human immunocompetent Organs-on-Chips platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

The paper demonstrates that human immunocompetent Organs-on-Chips can predict safety liabilities of T-cell bispecific antibodies targeting tumor antigens.

A Micro-engineered Human Colon Intestine-Chip Platform to Study Leaky Barrier

This paper introduces a Colon Intestine-Chip platform to study leaky gut by combining organoids and Organ-on-Chip technologies, showing its response to inflammatory cytokines and IL-22.

A novel Organ-Chip system emulates three-dimensional architecture of the human epithelia and allows fine control of mechanical forces acting on it.

This paper introduces a new Organ-Chip system that emulates the 3D architecture of human epithelia and allows precise control of mechanical forces, demonstrating its feasibility with skin and alveolar epithelial cells.

Modeling Alpha-Synuclein Pathology in a Human Brain-Chip to Assess Blood-Brain Barrier Disruption in Parkinson's Disease

The paper develops a human Brain-Chip model of Parkinson's disease to study blood-brain barrier disruption and synucleinopathy mechanisms.

Organoid-derived Duodenum Intestine-Chip for preclinical drug assessment in a human relevant system

The paper develops a human Duodenum Intestine-Chip model to better predict drug metabolism and drug-drug interactions by emulating intestinal functions and CYP450 induction.