Author

J. P. Hazra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:biophysical modeling· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

S. RAKSHIT· 4 shared A. Sagar· 3 shared N. Arora· 2 shared A. Chaudhuri· 1 shared A. Garg· 1 shared A. Kumar· 1 shared Ashish· 1 shared D. Deb· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersBiophysics

S. RAKSHIT

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Author profile →

4 papers

Recent·Most cited

Tip-links serve as force-pass filter to fulfil the role of gating-springs

N. Arora, J. P. Hazra, S. Roy, G. K. Bhati, S. Gupta, A. Chaudhuri, A. Sagar, S. RAKSHIT

The paper investigates the mechanical behavior of tip-links in hearing, showing they act as low-force pass filters through slip-ideal-slip bond dynamics and their role in gating-springs.

bioRxiv · Aug 10, 2022 · PreprintBiophysics

Variable Mutations at the p53-R273 Oncogeic Hotspot Position Leads to Altered Properties

A. Garg, J. P. Hazra, M. Sannigrahi, S. Rakshit, S. Sinha

This study examines how different R273 mutations in p53 affect structural stability, aggregation, and toxicity, revealing distinct molecular mechanisms that may contribute to varied cancer outcomes.

bioRxiv · Jun 26, 2019Biophysics

Broken force dispersal network in tip-links by the mutations induces hearing-loss

J. P. Hazra, A. Sagar, N. Arora, D. Deb, S. P. Kaur, S. Rakshit

The paper investigates how mutations in tip-link proteins disrupt force transmission in inner ear sensors, leading to hearing loss, and shows that Ca2+ can restore function in mutants.

bioRxiv · Apr 19, 2019Biophysics

Molecular mechanism of cell-cell adhesion mediated by cadherin-23

G. S. Singaraju, A. Kumar, J. S. Samuel, A. Sagar, J. P. Hazra, M. K. Sannigrahi, R. M. Yennamalli, Ashish, S. Rakshit

This study identifies a novel antiparallel-binding interface of cadherin-23 homodimer and shows how mutations in this interface affect cell-cell adhesion and cancer.

bioRxiv · Oct 24, 2017 · PreprintBiophysics