S. Rakshit

A host AAA-ATPase exhibits bacteriolytic activity for clearance of microbial infection

The paper shows that the host AAA-ATPase VCP/p97 has bacteriolytic activity by mechanically extracting ubiquitinated proteins from bacterial membranes, leading to microbial clearance in a mouse sepsis model.

Redefining the structure of tip-links in hair-cells

The paper redefines the structure of tip-links in hair-cells by showing cadherin-23 forms trans-homodimers rather than cis-dimers, while protocadherin-15 remains as cis-dimers.

Differences in anti-viral immune responses in individuals of Indian and European origin: relevance for the COVID-19 pandemic

The paper compares anti-viral immune responses between individuals of Indian and European origin, finding differences in chromatin accessibility and transcriptional responses to viral stimulation, which may explain variations in COVID-19 susceptibility.

Tip-links serve as force-pass filter to fulfil the role of gating-springs

The paper investigates the mechanical behavior of tip-links in hearing, showing they act as low-force pass filters through slip-ideal-slip bond dynamics and their role in gating-springs.

Barrier-free liquid condensates of nanocatalysts as effective concentrators of catalysis

This study demonstrates barrier-free liquid condensates of nanocatalysts that enhance catalytic efficiency through molecular confinement without physicochemical barriers.

Transient interactions drive the lateral clustering of Cadherin-23 on membrane

This study shows that transient hydrophobic interactions drive lateral clustering of cadherin-23 on membranes, enhancing cell adhesion without requiring specific cis-dimer interactions.

Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis

This paper shows that hydrogen sulfide (H2S) prevents HIV rebound by maintaining mitochondrial function and redox balance, and that H2S donors can suppress viral reactivation in ART-suppressed individuals.

Variable Mutations at the p53-R273 Oncogeic Hotspot Position Leads to Altered Properties

This study examines how different R273 mutations in p53 affect structural stability, aggregation, and toxicity, revealing distinct molecular mechanisms that may contribute to varied cancer outcomes.

Broken force dispersal network in tip-links by the mutations induces hearing-loss

The paper investigates how mutations in tip-link proteins disrupt force transmission in inner ear sensors, leading to hearing loss, and shows that Ca2+ can restore function in mutants.

Molecular mechanism of cell-cell adhesion mediated by cadherin-23

This study identifies a novel antiparallel-binding interface of cadherin-23 homodimer and shows how mutations in this interface affect cell-cell adhesion and cancer.