Author

J. P. Iredale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1

Frequent Co-Authors

D. J. Mole· 2 shared A. M. Thomson· 1 shared B. E. Henderson· 1 shared C. J. Weston· 1 shared C. M. Duff· 1 shared C. P. Ponting· 1 shared E. F. Dora· 1 shared E. M. Harrison· 1 shared

Activity by Year

2017-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

D. J. Mole

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3 papers

Recent·Most cited

qPaLM: quantifying occult microarchitectural relationships in histopathological landscapes

T. J. Kendall, C. M. Duff, A. M. Thomson, J. P. Iredale

This paper introduces qPaLM, a framework to quantify microarchitectural relationships in histopathological images without training, enabling mechanistic insights and machine learning classification.

bioRxiv · Nov 2, 2019 · PreprintPathology

Resolving the fibrotic niche of human liver cirrhosis using single-cell transcriptomics

P. Ramachandran, R. Dobie, J. R. Wilson-Kanamori, E. F. Dora, B. E. Henderson, R. S. Taylor, K. P. Matchett, J. R. Portman, M. Efremova, R. Vento-Tormo, N. T. Luu, C. J. Weston, P. N. Newsome, E. M. Harrison, D. J. Mole, , N. C. Henderson

This study uses single-cell transcriptomics to identify novel fibrotic cell types and interactions in human liver cirrhosis, revealing potential therapeutic targets.

Nature · Oct 9, 2019Peer-reviewedImmunology

Detecting Drug-Target Binding In Cells Using Fluorescence Activated Cell Sorting Coupled With Mass Spectrometry Analysis

K. Wilson, S. P. Webster, J. P. Iredale, X. Zheng, N. Z. M. Homer, N. Pham, M. Auer, D. J. Mole

This paper introduces a new method called TAPS to assess drug-target binding in cells, demonstrating its effectiveness with the challenging KMO target.

bioRxiv · Apr 3, 2017Pharmacology & Toxicology