G. Kulkarni

Qualifying a human Liver-Chip for predictive toxicology: Performance assessment and economic implications

The paper evaluates a Liver-Chip's ability to predict drug-induced liver injury and estimates its economic impact in pharmaceutical R&D.

Hopanoids confer robustness to physicochemical variability in the niche of the plant symbiont Bradyrhizobium diazoefficiens

This study shows that hopanoids in Bradyrhizobium diazoefficiens provide robustness to environmental variability in soil, explaining discrepancies between in vitro and in planta results.

A Micro-engineered Human Colon Intestine-Chip Platform to Study Leaky Barrier

This paper introduces a Colon Intestine-Chip platform to study leaky gut by combining organoids and Organ-on-Chip technologies, showing its response to inflammatory cytokines and IL-22.

Liver-Chip: Reproducing Human and Cross-Species Toxicities

The paper designs Liver-Chips for rat, dog, and human to replicate species-specific liver toxicities and predict human relevance.

Energy conservation via hydrogen cycling in the methanogenic archaeon Methanosarcina barkeri

This study provides direct evidence that Methanosarcina barkeri uses hydrogen cycling to generate a proton motive force, supporting energy conservation via H2 production and consumption.

Genetic, biochemical, and molecular characterization of Methanosarcina barkeri mutants lacking three distinct classes of hydrogenase

The paper characterizes Methanosarcina barkeri mutants lacking hydrogenases, showing their non-essential but significant role in methanol growth and revealing redox state sensing mechanisms.