P. Haberkant

Trifunctional sphinganine: a new tool to dissect sphingolipid function

The paper develops multifunctional derivatives of sphingosine and sphinganine to study their cellular roles, revealing distinct protein interactomes and spatiotemporal distributions.

Global RNA interactome of nitrogen starved Escherichia coli uncovers a conserved post-transcriptional regulatory axis required for optimal growth recovery

This study maps the Hfq-mediated RNA interactome in nitrogen-starved E. coli, revealing SdsR's role in post-transcriptional regulation during long-term growth arrest and recovery.

Flow in fetoplacental microvessels in vitro enhances perfusion, barrier function, and matrix stability

This study develops a 3D in vitro model of human placental microvessels and shows that flow enhances perfusion, barrier function, and matrix stability.

Dextromethorphan inhibits collagen transport in the endoplasmic reticulum eliciting an anti-fibrotic response in ex-vivo and in vitro models of pulmonary fibrosis

This study shows Dextromethorphan reduces collagen deposition in fibrotic models by inhibiting collagen trafficking in the endoplasmic reticulum.

Mitochondrial dysfunction rapidly modulates the abundance and thermal stability of cellular proteins

The paper develops ppTPP to study mitochondrial dysfunction's effects on proteome stability and abundance, revealing group-specific response patterns in eukaryotic cells.

A new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress

The paper introduces a method to isolate organellar membranes from yeast and uses it to study lipid composition and stress responses in the endoplasmic reticulum and vacuolar membranes.

Lysosome-targeted lipid probes reveal sterol transporters NPC1 and LIMP2 as sphingosine transporters

The paper develops lipid probes to study sphingosine transport, revealing NPC1 and LIMP2 as sphingosine transporters and showing their role in cholesterol efflux.

Increased levels of the mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol

The paper shows that overexpressing Mia40 reduces toxic polyQ protein aggregates in yeast and human cells by competing for chaperone and proteasome resources.

Stroma transcriptomic and proteomic profile of prostate cancer metastasis xenograft models reveals conservation of bonemicroenvironment signatures

The paper identifies tenascin C as a stromal marker associated with metastasis in prostate cancer xenograft models and shows its prognostic potential in patient samples.