Author

J. P. Zewe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1

Frequent Co-Authors

R. C. Wills· 3 shared G. R. Hammond· 2 shared J. Pacheco· 2 shared A. C. Cassidy· 1 shared B. Goulden· 1 shared B. Renganathan· 1 shared C. P. Doyle· 1 shared G. Hammond· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCell Biology

R. C. Wills

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4 papers

Recent·Most cited

Gigaxonin is required for intermediate filament transport

B. Renganathan, J. P. Zewe, Y. Cheng, M. Kittisopikul, P. Opal, K. M. Ridge, V. I. Gelfand

This study shows that gigaxonin is essential for intermediate filament transport by kinesin-1, and its loss leads to IF accumulation due to increased soluble vimentin oligomers.

bioRxiv · Aug 19, 2022Cell Biology

A Novel Homeostatic Mechanism Tunes PI(4,5)P2-dependent Signaling at the Plasma Membrane

R. C. Wills, C. P. Doyle, J. P. Zewe, J. Pacheco, S. D. Hansen, G. R. Hammond

The paper identifies PIP4K as a sensor and negative regulator of PI(4,5)P2 synthesis, revealing a homeostatic mechanism that tunes membrane functions.

bioRxiv · Jun 30, 2022Cell Biology

Free diffusion of PI(4,5)P2 in the plasma membrane in the presence of high density effector protein complexes

J. Pacheco, A. C. Cassidy, J. P. Zewe, R. C. Wills, G. R. Hammond

The paper measures PI(4,5)P2 diffusion in the plasma membrane and finds that it diffuses rapidly even in regions with high effector protein density, suggesting free diffusion rather than spatial segregation.

bioRxiv · Jan 7, 2022Cell Biology

SAC1 Degrades its Lipid Substrate PtdIns4P in the Endoplasmic Reticulum to Maintain a Steep Chemical Gradient with Donor Membranes

J. P. Zewe, R. C. Wills, S. Sangappa, B. Goulden, G. Hammond

This paper shows SAC1 degrades PtdIns4P in the ER to maintain a gradient, revealing its obligate cis activity in lipid traffic.

bioRxiv · Jan 31, 2018Cell Biology