S. D. Hansen

Molecular basis of product recognition during PIP5K-mediated production of PI(4,5)P2 with positive feedback

This study investigates how PIP5K motifs recognize PI(4,5)P2 to regulate membrane association and catalysis through a two-step binding model.

Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases

This study investigates how PI3Kβ integrates signals from RTKs, Gβγ, and Rho-family GTPases, revealing synergistic activation through allosteric regulation.

Mechanisms controlling membrane recruitment and activation of autoinhibited SHIP1

This study uses single molecule TIRF microscopy to investigate how lipid and protein interactions control SHIP1 membrane recruitment and activation, revealing its autoinhibition and relief mechanisms.

Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain

This study identifies the helical domain of p110γ as an allosteric regulator of PI3Kγ activity, showing distinct roles in p110γ-p84 and p110γ-p101 complexes through phosphorylation or nanobody binding.

A Novel Homeostatic Mechanism Tunes PI(4,5)P2-dependent Signaling at the Plasma Membrane

The paper identifies PIP4K as a sensor and negative regulator of PI(4,5)P2 synthesis, revealing a homeostatic mechanism that tunes membrane functions.

Membrane-mediated dimerization potentiates PIP5K lipid kinase activity

This study shows that PIP5K dimerization enhances its catalytic efficiency and stochastic behavior through membrane-mediated interactions with PI(4,5)P2.

Structure of the phosphoinositide 3-kinase p110γ-p101 complex reveals molecular mechanism of GPCR activation

The paper reports the cryo-EM structure of the p110γ-p101 complex, revealing how GPCR activation is mediated through interactions with Gβγ and identifying potential therapeutic targets.

Bacterial Microtubules Exhibit Polarized Growth, Mixed-Polarity Bundling, and Destabilization by GTP Hydrolysis

This study characterizes bacterial microtubules (bMTs) from Prosthecobacter, showing polarized growth, mixed-polarity bundling, and GTP-dependent destabilization, suggesting ancestral eukaryotic tubulin dynamics.