This study identifies GRK2's role in hair follicle homeostasis by showing its deletion leads to cyst formation, stem cell disruption, and hair loss in mice.

bioRxiv · Apr 11, 2024Cell Biology

Evaluating treatments for the protection of grapevine pruning wounds from natural infection by trunk disease fungi

C. Leal, R. Bujanda, B. L. Manzanares, S. Ojeda, M. Berbegal, A. V. Llop, L. G. Santesteban, J. Palacios, D. Gramaje

This study evaluates the effectiveness of fungicides and biological control agents in preventing natural fungal infections of grapevine pruning wounds in field conditions.

bioRxiv · Feb 27, 2024Microbiology

Hidden conformations differentiate day and night in a circadian pacemaker

J. Swan, C. Sandate, A. Chavan, A. Freeberg, D. Etwaru, D. Ernst, J. Palacios, S. Golden, A. LiWang, G. C. Lander, C. Partch

The paper uses cryo-EM to reveal structural changes in KaiC during day and night that regulate clock protein binding and circadian rhythms.

bioRxiv · Sep 14, 2021 · PreprintBiochemistry

IN VIVO ANALYSIS OF THE ROLE OF GASDERMIN-B (GSDMB) IN CANCER USING NOVEL KNOCK-IN MOUSE MODELS

D. SARRIO, A. ROJO-SEBASTIAN, A. TEIJO, M. PEREZ-LOPEZ, E. DIAZ-MARTIN, L. MARTINEZ, S. MORALES, P. GARCIA-SANZ, J. PALACIOS, G. MORENO-BUENO

This study uses novel knock-in mouse models to investigate GSDMB2's role in cancer, finding it does not significantly drive tumorigenesis but may reduce gastric carcinogenesis.

bioRxiv · May 27, 2021Cancer Biology