J. Qi

This study designs excretable AIE dots for deep-tissue imaging in marmosets, demonstrating their biocompatibility and excretion capabilities.

This paper develops an electronic blood vessel using flexible bio-degradable circuitry to enhance endothelization and enable gene delivery, showing good biocompatibility and patency in a rabbit model.

The paper determines the near-atomic structure of the SARS-CoV-2 polymerase complex and shows reduced activity and thermostability compared to SARS-CoV.

The paper uses computational simulations to study the binding dynamics between human ACE2 and the SARS-CoV-2 spike protein's RBD, revealing critical residues and binding modes.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

This study shows BET bromodomain proteins drive inflammatory gene networks in cardiac fibroblasts, contributing to genetic dilated cardiomyopathy, and that JQ1, a BET inhibitor, reduces disease progression.

This study identifies SHMT1 and SHMT2 as therapeutic targets in T-ALL by showing their inhibition impairs leukemia progression and is effective despite methotrexate resistance.

The paper models leukemia transcriptome dynamics in a state-space to identify critical points that predict disease development.

This study establishes a mouse orthodontic retention model and shows that longer retention and anti-c-Fms antibody reduce orthodontic relapse.

This paper introduces a relative Patlak plot method for dynamic PET that eliminates the need for early-time input function, enabling more efficient parametric imaging with equivalent clinical utility.

The paper identifies a potent and selective ROR1-targeting scFv, R11, and determines its structure bound to ROR1, showing its antitumor activity in vitro and in vivo.

The paper shows auxin signaling regulates cambium activity through specific transcription factors, influencing stem cell number and wood formation.