J. R. Hesselberth

Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breast

This study identifies MDC1's role in ER co-regulation and DNA repair dysfunction in ILC, linking it to PARP inhibitor sensitivity.

MARCO+ lymphatic endothelial cells sequester arboviruses to limit viremia and viral dissemination

This study identifies MARCO+ lymphatic endothelial cells as key in limiting arboviral viremia by sequestering alphavirus particles in draining lymph nodes and the liver.

Neoplastic and Immune single cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma.

The paper uses single-cell transcriptomics to identify subgroup-specific neoplastic and immune cell heterogeneity in childhood medulloblastoma.

Molecular tracking devices quantify antigen distribution and archiving in the lymph node

The paper develops molecular tracking devices to study antigen distribution and archiving in lymph nodes, revealing antigen retention in LECs and stromal cells via caveolar endocytosis.

Physiologic RNA Targets and Refined Sequence Specificity of Coronavirus EndoU

This study identifies the RNA targets of Coronavirus EndoU, showing it cleaves viral RNA at UA and CA sequences to suppress antiviral responses.

Simultaneous measurement of biochemical phenotypes and gene expression in single cells

The paper develops a method to simultaneously measure biochemical activities and mRNA abundance in single cells, revealing DNA repair heterogeneity in human lymphocytes.