S. Mehrotra

Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breast

This study identifies MDC1's role in ER co-regulation and DNA repair dysfunction in ILC, linking it to PARP inhibitor sensitivity.

Reviving immunogenic cell death upon targeting TACC3 enhances T-DM1 response in HER2-positive breast cancer

This study shows that T-DM1 induces immunogenic cell death (ICD) in HER2-positive breast cancer, which is lost in resistance, and that targeting TACC3 restores ICD and enhances T-DM1 response.

Impaired T-cell and antibody immunity after COVID-19 infection in chronically immunosuppressed transplant recipients

This study evaluates T-cell and antibody immunity to SARS-CoV-2 in transplant recipients, finding impaired responses and increased CMV co-infection risk post-infection.

Mediator of DNA damage checkpoint 1 (MDC1) is a novel estrogen receptor co-regulator in invasive lobular carcinoma of the breast

This study identifies MDC1 as a novel ER co-regulator in ILC that promotes ER-driven proliferation and anti-estrogen resistance.

Identification of human CD4+ T cell populations with distinct antitumor activity

The paper identifies human CD4+ T cell populations with distinct antitumor activity, showing CD26high T cells are epigenetically and transcriptionally different from Th17 cells and are more effective in tumor therapy.