Author

L. R. Myler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

A. E. Dolan· 1 shared A. Ke· 1 shared A. L. Richer· 1 shared C. E. Rowland· 1 shared C. S. Nesiba· 1 shared E. Anslyn· 1 shared E. S. Sokol· 1 shared E. T. Hernandez· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBiophysics

A. E. Dolan

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breast

J. L. Sottnik, M. T. Shackleford, C. S. Nesiba, A. L. Richer, Z. Fleischmann, J. M. Swartz, C. E. Rowland, M. Musick, R. Fu, L. R. Myler, P. L. Opresko, S. Mehrotra, E. S. Sokol, J. R. Hesselberth, J. R. Diamond, M. J. Sikora

This study identifies MDC1's role in ER co-regulation and DNA repair dysfunction in ILC, linking it to PARP inhibitor sensitivity.

bioRxiv · Oct 29, 2023Cancer Biology

RPA phosphorylation regulates DNA resection

M. M. Soniat, L. R. Myler, T. T. Paull, I. J. Finkelstein

This study identifies RPA phosphorylation as a mechanism that limits DNA resection by regulating BLM helicase activity in human cells.

bioRxiv · Jan 17, 2019Biophysics

Assembly and translocation of a CRISPR-Cas primed acquisition complex

M. W. Brown, K. E. Dillard, Y. Xiao, A. E. Dolan, E. T. Hernandez, S. Dahlhauser, Y. Kim, L. R. Myler, E. Anslyn, A. Ke, I. Finkelstein

This study uses single-molecule techniques to characterize the type I-E CRISPR-Cas primed acquisition complex, revealing how Cascade, Cas3, and Cas1-Cas2 coordinate to recognize and acquire foreign DNA.

bioRxiv · Oct 26, 2017Biophysics