Author

J. R. Keown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

E. Fodor· 3 shared J. M. Grimes· 3 shared H. Fan· 2 shared L. Carrique· 2 shared A. Artuyants· 1 shared A. J. te Velthuis· 1 shared A. Kotecha· 1 shared A. P. Walker· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersMicrobiology

E. Fodor

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Author profile →

5 papers

Recent·Most cited

Structural Characterization of the Full-length Hantaan Virus Polymerase

J. R. Keown, L. Carrique, B. Nilsson-payant, E. Fodor, J. M. Grimes

This study characterizes the structure of the full-length Hantaan virus polymerase using cryo-EM, revealing conformational states relevant to replication and transcription.

bioRxiv · Jun 9, 2023 · PreprintBiochemistry

Identification of guanylyltransferase activity in the SARS-CoV-2 RNA polymerase

A. P. Walker, H. Fan, J. R. Keown, J. Grimes, E. Fodor

This paper identifies the guanylyltransferase activity in SARS-CoV-2 RNA polymerase and shows remdesivir triphosphate inhibits both GTase and polymerase functions.

bioRxiv · Mar 17, 2021 · PreprintMicrobiology

A high resolution view of an adolescent flavivirus

M. Renner, W. Dejnirattisai, L. Carrique, I. Serna Martin, D. Karia, S. L. Ilca, S. F. Ho, A. Kotecha, J. R. Keown, J. Mongkolsapaya, G. R. Screaton, J. M. Grimes

This study presents high-resolution cryo-EM structures of immature and mature flaviviruses, revealing structural changes during maturation and the role of pH in conformational rearrangements.

bioRxiv · Jun 7, 2020 · PreprintMicrobiology

Enisamium is a small molecule inhibitor of the influenza A virus and SARS-CoV-2 RNA polymerases

A. Walker, H. Fan, J. R. Keown, V. Margitich, J. M. Grimes, E. Fodor, A. J. te Velthuis

This paper shows enisamium and its metabolite VR17-04 inhibit RNA polymerases of influenza A and SARS-CoV-2, with VR17-04 matching remdesivir's efficacy against SARS-CoV-2.

bioRxiv · Apr 21, 2020 · PreprintMicrobiology

The protozoan Trichomonas vaginalis targets bacteria with laterally-acquired NlpC/P60 peptidoglycan hydrolases

J. Pinheiro, J. Biboy, W. Vollmer, R. P. Hirt, J. R. Keown, A. Artuyants, D. C. Goldstone, A. Simoes-Barbosa

This study identifies laterally-acquired NlpC/P60 peptidoglycan hydrolases in Trichomonas vaginalis that degrade bacterial peptoglycan, enabling the parasite to compete with bacteria in mixed cultures.

bioRxiv · May 11, 2018Microbiology