Author

J. Mongkolsapaya

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Immunology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 8 Organism:human· 4 Assay:proteomics· 4 Organism:virus· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:microscopy & imaging analysis· 2

Frequent Co-Authors

P. Supasa· 7 shared W. Dejnirattisai· 7 shared G. R. Screaton· 5 shared G. Screaton· 5 shared D. I. Stuart· 4 shared D. Zhou· 4 shared A. Townsend· 3 shared C. Liu· 3 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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7 shared papersMicrobiology

P. Supasa

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Cooperativity and induced oligomerisation control the interaction of SARS- CoV-2 with its cellular receptor and patient-derived antibodies

R. Asor, A. Olerinyova, S. A. Burnap, M. S. Kushwah, F. Soltermann, L. P. Rudden, M. Hensen, S. Vasiljevic, J. Brun, M. Hill, L. Chang, W. Dejnirattisai, P. Supasa, J. Mongkolsapaya, D. Zhou, , P. Kukura

The paper investigates how multivalent interactions between SARS-CoV-2 spike protein, ACE2 receptor, and patient-derived antibodies influence viral entry and antibody inhibition.

bioRxiv · Sep 14, 2023 · PreprintBiophysics

Analysis of emergent bivalent antibody binding identifies the molecular reach as a critical determinant of SARS-CoV-2 neutralisation potency

A. Huhn, D. A. Nissley, D. B. Wilson, M. A. Kutuzov, R. Donat, T. K. Tan, Y. Zhang, M. I. Barton, C. Liu, W. Dejnirattisai, P. Supasa, J. Mongkolsapaya, A. Townsend, W. S. James, G. Screaton, , O. Dushek

This paper develops a bivalent binding model to analyze how molecular reach affects SARS-CoV-2 neutralization potency across antibodies.

bioRxiv · Sep 6, 2023 · PreprintImmunology

Functional analysis of flavivirus replicase by deep mutational scanning of dengue NS5

A. Suphatrakul, P. Posiri, N. Srisuk, R. Nantachokchawapan, S. Onnome, J. Mongkolsapaya, B. Siridechadilok

The paper uses deep mutational scanning to analyze dengue virus NS5, identifying conserved residues and potential plasticity in its replicase activity, with implications for antiviral strategies.

bioRxiv · Mar 7, 2023 · PreprintMicrobiology

Inhibition of Phosphodiesterase 12 results in Antiviral Activity against several RNA Viruses including SARS-CoV-2.

P. Karayiannis, M. Thursz, F. Sadiq, J. Tree, D. Beasley, W. Dejnirattisai, J. Mongkolsapaya, G. Screaton, M. Wand, M. Elmore, C. Miles, I. Matthews, H. Thomas

The paper shows that PDE12 inhibitors increase RNAseL activity and inhibit replication of multiple RNA viruses including SARS-CoV-2 in vitro and in vivo.

bioRxiv · Sep 23, 2022Microbiology

Further antibody escape by Omicron BA.4 and BA.5 from vaccine and BA.1 serum

A. Tuekprakhon, J. Huo, R. Nutalai, A. Dijokaite-Guraliuc, D. Zhou, H. M. Ginn, M. Sekvaraj, C. Liu, A. J. Mentzer, P. Supasa, H. M. E. Duyvesteyn, R. Das, D. Skelly, T. G. Ritter, A. Amini, , G. R. Screaton

This study shows that BA.4 and BA.5 variants are more resistant to neutralization by vaccine and BA.1 immune sera compared to BA.1 and BA.2.

bioRxiv · May 21, 2022 · PreprintMicrobiology

The ChAdOx1 vectored vaccine, AZD2816, induces strong immunogenicity against SARS-CoV-2 Beta (B.1.351) and other variants of concern in preclinical studies.

A. J. Spencer, S. Morris, M. Ulaszewska, C. Powers, R. Kaliath, C. D. Bissett, A. Truby, N. Thakur, J. Newman, E. R. Allen, I. Rudiansyah, C. Lui, W. Dejnirattisai, J. Mongkolsapaya, H. Davies, , T. Lambe

bioRxiv · Jun 8, 2021Immunology

Native-like SARS-CoV-2 spike glycoprotein expressed by ChAdOx1 nCoV-19/AZD1222 vaccine

Y. Watanabe, L. Mendonca, E. R. Allen, A. Howe, M. Lee, J. D. Allen, H. Chawla, D. Pulido, F. Donnellan, H. Davies, M. Ulaszewska, S. Belij-Rammerstorfer, S. Morris, A.-S. Krebs, W. Dejnirattisai, , M. Crispin

This study characterizes the structure, conformation, and glycosylation of the SARS-CoV-2 spike protein expressed by the ChAdOx1 nCoV-19/AZD1222 vaccine, confirming its native-like properties.

bioRxiv · Jan 15, 2021Microbiology

Neutralization of SARS-CoV-2 by destruction of the prefusion Spike

J. Huo, Y. Zhao, J. Ren, D. Zhou, H. M. E. Duyvesteyn, H. M. Ginn, L. Carrique, T. Malinauskas, R. R. Ruza, P. N. Shah, T. K. Tan, P. Rijal, N. Coombes, K. Bewley, J. Radecke, , D. I. Stuart

This paper identifies CR3022 as a monoclonal antibody that neutralizes SARS-CoV-2 by destroying its prefusion Spike conformation, suggesting therapeutic potential.

Cell Host & Microbe · Sep 1, 2020Peer-reviewedMicrobiology

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

D. Zhou, H. M. E. Duyvesteyn, C.-P. Chen, C.-G. Huang, T.-H. Chen, S.-R. Shih, Y.-C. Lin, C.-Y. Cheng, S.-H. Cheng, Y.-C. Huang, T.-Y. Lin, C. Ma, J. Huo, L. Carrique, T. Malinauskas, , K.-Y. A. Huang

This paper identifies an antibody, EY6A, from a convalescent patient that neutralizes SARS-CoV-2 and cross-reacts with SARS-CoV-1 by binding a conserved epitope on the Spike protein.

bioRxiv · Jun 12, 2020Microbiology

A high resolution view of an adolescent flavivirus

M. Renner, W. Dejnirattisai, L. Carrique, I. Serna Martin, D. Karia, S. L. Ilca, S. F. Ho, A. Kotecha, J. R. Keown, J. Mongkolsapaya, G. R. Screaton, J. M. Grimes

This study presents high-resolution cryo-EM structures of immature and mature flaviviruses, revealing structural changes during maturation and the role of pH in conformational rearrangements.

bioRxiv · Jun 7, 2020 · PreprintMicrobiology

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.

T. Dong, Y. Peng, A. J. Mentzer, G. Liu, X. Yao, Z. Yin, D. Dong, W. Dejnirattisai, L. Turtle, T. Rostron, K. Subramaniam, P. Thomson, P. Zhang, C. Dold, J. Ratcliff, , Lopez-C

This study examines T cell immunity in UK COVID-19 patients, finding stronger and broader memory T cell responses in severe cases, with implications for vaccine design.

bioRxiv · Jun 5, 2020Immunology