Author

J. M. Grimes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Approach:microscopy & imaging analysis· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. R. Keown· 3 shared E. Fodor· 2 shared L. Carrique· 2 shared A. J. te Velthuis· 1 shared A. Kotecha· 1 shared A. Walker· 1 shared B. Nilsson-payant· 1 shared C. A. Okolo· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersMicrobiology

J. R. Keown

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural Characterization of the Full-length Hantaan Virus Polymerase

J. R. Keown, L. Carrique, B. Nilsson-payant, E. Fodor, J. M. Grimes

This study characterizes the structure of the full-length Hantaan virus polymerase using cryo-EM, revealing conformational states relevant to replication and transcription.

bioRxiv · Jun 9, 2023 · PreprintBiochemistry

A high resolution view of an adolescent flavivirus

M. Renner, W. Dejnirattisai, L. Carrique, I. Serna Martin, D. Karia, S. L. Ilca, S. F. Ho, A. Kotecha, J. R. Keown, J. Mongkolsapaya, G. R. Screaton, J. M. Grimes

This study presents high-resolution cryo-EM structures of immature and mature flaviviruses, revealing structural changes during maturation and the role of pH in conformational rearrangements.

bioRxiv · Jun 7, 2020 · PreprintMicrobiology

Enisamium is a small molecule inhibitor of the influenza A virus and SARS-CoV-2 RNA polymerases

A. Walker, H. Fan, J. R. Keown, V. Margitich, J. M. Grimes, E. Fodor, A. J. te Velthuis

This paper shows enisamium and its metabolite VR17-04 inhibit RNA polymerases of influenza A and SARS-CoV-2, with VR17-04 matching remdesivir's efficacy against SARS-CoV-2.

bioRxiv · Apr 21, 2020 · PreprintMicrobiology

Correlative cryo-structured illumination fluorescence microscopy and soft X-ray tomography elucidates reovirus intracellular release pathway

M. Harkiolaki, I. Kounatidis, M. L. Stanifer, M. A. Phillips, P. Paul-Gilloteau, X. Helligenstein, H. Wang, C. A. Okolo, T. Fish, M. C. Spink, D. I. Stuart, I. Davis, S. Boulant, J. M. Grimes, I. M. Dobbie

This study develops a correlative imaging platform combining cryo-SIM and SXT to study reovirus release from intracellular vesicles, revealing novel virus-induced structures.

bioRxiv · Jan 13, 2020Cell Biology