Author

L. Carrique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Biophysics· 2 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Research Focus:protein structure prediction· 5 Assay:structural biology· 5 Organism:virus· 5 Assay:cryo-EM· 4 Approach:microscopy & imaging analysis· 3 Approach:statistical model· 3

Frequent Co-Authors

D. I. Stuart· 3 shared D. Zhou· 3 shared E. E. Fry· 3 shared G. R. Screaton· 3 shared H. M. E. Duyvesteyn· 3 shared J. Huo· 3 shared J. Mongkolsapaya· 3 shared J. Radecke· 3 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

D. I. Stuart

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Author profile →

10 papers

Recent·Most cited

Structural and functional characterisation of the interaction between the influenza A virus RNA polymerase and the CTD of host RNA Polymerase II

J. Keown, A. Baazaoui, M. Sebesta, R. Stefl, L. Carrique, E. Fodor, J. Grimes

This study characterizes the structural and functional interaction between influenza A virus RNA polymerase and host RNA Polymerase II CTD, identifying key residues and their roles in transcription and replication.

bioRxiv · Nov 29, 2023 · PreprintMicrobiology

Structure of the N-RNA/P interface reveals mode of L/P attachment to the nucleocapsid of human metapneumovirus

J. D. Whitehead, H. Decool, C. Leyrat, L. Carrique, J. Fix, J.-F. Eleouet, M. Galloux, M. Renner

The paper determines the structure of the N-RNA/P triple complex in human metapneumovirus, revealing how the polymerase attaches to the RNA template and providing a basis for therapeutic design.

bioRxiv · Jun 10, 2023 · PreprintMicrobiology

Structural Characterization of the Full-length Hantaan Virus Polymerase

J. R. Keown, L. Carrique, B. Nilsson-payant, E. Fodor, J. M. Grimes

This study characterizes the structure of the full-length Hantaan virus polymerase using cryo-EM, revealing conformational states relevant to replication and transcription.

bioRxiv · Jun 9, 2023 · PreprintBiochemistry

LipIDens: Simulation assisted interpretation of lipid densities in cryo-EM structures of membrane proteins.

T. B. Ansell, W. Song, C. E. Coupland, L. Carrique, R. A. Corey, A. L. Duncan, C. K. Cassidy, M. M. G. Guerts, T. Rasmussen, A. B. Ward, C. Siebold, P. J. Stansfeld, M. Sansom

LipIDens uses MD simulations to interpret lipid-like densities in cryo-EM maps of membrane proteins, revealing protein-lipid interactions.

bioRxiv · Jun 30, 2022Biophysics

Structure and Mechanism of Hedgehog Acyl Transferase

C. E. Coupland, S. A. Andrei, T. B. Ansell, L. Carrique, P. Kumar, L. Sefer, R. A. Schwab, E. F. X. Byrne, E. Pardon, J. Steyaert, A. I. Magee, M. S. P. Sansom, E. W. Tate, C. Siebold

The paper presents the cryo-EM structure of HHAT, revealing its mechanism for transferring palmitate to SHH and identifying a heme group essential for its function.

bioRxiv · Jul 8, 2021 · PreprintBiophysics

Neutralization of SARS-CoV-2 by destruction of the prefusion Spike

J. Huo, Y. Zhao, J. Ren, D. Zhou, H. M. E. Duyvesteyn, H. M. Ginn, L. Carrique, T. Malinauskas, R. R. Ruza, P. N. Shah, T. K. Tan, P. Rijal, N. Coombes, K. Bewley, J. Radecke, , D. I. Stuart

This paper identifies CR3022 as a monoclonal antibody that neutralizes SARS-CoV-2 by destroying its prefusion Spike conformation, suggesting therapeutic potential.

Cell Host & Microbe · Sep 1, 2020Peer-reviewedMicrobiology

The SARS-CoV-2 Spike harbours a lipid binding pocket which modulates stability of the prefusion trimer

L. Carrique, H. M. E. Duyvesteyn, T. Malinaukas, Y. Zhao, J. Ren, D. Zhou, T. S. Walter, J. Radecke, J. Huo, R. Ruza, P. N. Shah, E. E. Fry, D. I. Stuart

The paper identifies a lipid-binding pocket in the SARS-CoV-2 Spike that stabilizes the prefusion trimer and shields neutralizing epitopes, suggesting it as a potential drug target.

bioRxiv · Aug 13, 2020 · PreprintMicrobiology

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

D. Zhou, H. M. E. Duyvesteyn, C.-P. Chen, C.-G. Huang, T.-H. Chen, S.-R. Shih, Y.-C. Lin, C.-Y. Cheng, S.-H. Cheng, Y.-C. Huang, T.-Y. Lin, C. Ma, J. Huo, L. Carrique, T. Malinauskas, , K.-Y. A. Huang

This paper identifies an antibody, EY6A, from a convalescent patient that neutralizes SARS-CoV-2 and cross-reacts with SARS-CoV-1 by binding a conserved epitope on the Spike protein.

bioRxiv · Jun 12, 2020Microbiology

A high resolution view of an adolescent flavivirus

M. Renner, W. Dejnirattisai, L. Carrique, I. Serna Martin, D. Karia, S. L. Ilca, S. F. Ho, A. Kotecha, J. R. Keown, J. Mongkolsapaya, G. R. Screaton, J. M. Grimes

This study presents high-resolution cryo-EM structures of immature and mature flaviviruses, revealing structural changes during maturation and the role of pH in conformational rearrangements.

bioRxiv · Jun 7, 2020 · PreprintMicrobiology

Parallel Evolution in the Emergence of Highly Pathogenic Avian Influenza A Viruses

M. Escalera-Zamudio, M. Golden, B. Gutierrez, J. Theze, J. Russell Keown, L. Carrique, T. A. Bowden, O. G. Pybus

This study identifies parallel mutations in avian influenza viruses associated with high pathogenicity using phylogenetic and statistical methods.

bioRxiv · Aug 22, 2019Evolutionary Biology