Author

J. R. Moffitt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Assay:spatial transcriptomics· 4 Research Focus:spatial domain detection· 3 Organism:mouse· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

G. Wang· 3 shared X. Zhuang· 3 shared A. C. Anderson· 1 shared A. Hsiao· 1 shared A. Misra· 1 shared A. Wang· 1 shared B. Bao· 1 shared C. Benoist· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersCell Biology

G. Wang

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Author profile →

5 papers

Recent·Most cited

Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling

P. Cadinu, K. N. Sivanathan, A. Misra, R. J. Xu, D. Mangani, E. Yang, J. M. Rone, K. Tooley, Y.-C. Kye, L. Bod, L. Geistlinger, T. Lee, N. Ono, G. Wang, L. Sanmarco, , R. Nowarski

The paper uses MERFISH to analyze gene expression in a mouse colitis model, revealing fibroblast trajectories and spatial remodeling during inflammation.

bioRxiv · May 8, 2023Immunology

Microbiome induced complement synthesized in the gut protects against enteric infections

M. Wu, W. Zheng, X. Song, B. Bao, Y. Wang, D. Ramanan, D. Yang, R. Liu, J. C. Macbeth, E. A. Do, W. A. Andrade, T. Yang, H.-S. Cho, F. S. Gazzaniga, M. Ilves, , D. L. Kasper

The paper shows gut microbiota regulate complement component 3 (C3) production in humans and mice, with intestinal C3 levels correlating with protection against enteric infections.

bioRxiv · Feb 2, 2023 · PreprintImmunology

Spatial organization of the transcriptome in individual neurons

G. Wang, C.-E. Ang, J. Fan, A. Wang, J. R. Moffitt, X. Zhuang

This study maps the spatial organization of RNA in individual neurons using MERFISH, revealing distinct transcriptome compositions and sub-dendritic RNA distribution patterns.

bioRxiv · Dec 7, 2020 · PreprintCell Biology

Multiplexed detection of RNA using MERFISH and branched DNA amplification

C. Xia, H. P. Babcock, J. R. Moffitt, X. Zhuang

This paper introduces a branched DNA amplification method for MERFISH to enhance RNA detection efficiency and performance.

bioRxiv · Dec 25, 2018Cell Biology

Multiplexed imaging of high density libraries of RNAs with MERFISH and expansion microscopy

G. Wang, J. R. Moffitt, X. Zhuang

This paper combines MERFISH with expansion microscopy to increase RNA measurement density and demonstrates accurate RNA identification in high-abundance libraries.

bioRxiv · Dec 22, 2017Cell Biology