J. S. Ayres

Fluoxetine promotes immunometabolic defenses to mediate host-pathogen cooperation during sepsis

This study shows fluoxetine protects against sepsis by increasing IL-10, which prevents metabolic issues in the heart.

Age-dependent roles of cardiac remodeling in sepsis defense and pathogenesis

This study shows that age affects disease tolerance mechanisms in sepsis, with a cardioprotective pathway in young mice causing heart damage in older mice.

Cooperation between physiological defenses and immune resistance produces asymptomatic carriage of a lethal bacterial pathogen

The paper shows physiological defenses and immune resistance work together to allow asymptomatic carriage of a lethal bacterial pathogen.

CD4+ T cells regulate sickness-induced anorexia and fat wasting during a chronic parasitic infection

This study identifies CD4+ T cells as regulators of sickness-induced anorexia and fat wasting during a chronic parasitic infection, revealing a decoupling between immune resistance and cachexia.

Fat specific adipose triglyceride lipase is necessary for iron-mediated lipolysis and lipid mobilization in response to negative energy balance

This study shows that fat-specific adipose triglyceride lipase is required for iron-induced lipolysis and lipid mobilization during negative energy balance.

Leptin signaling regulates physiological damage and host-pathogen cooperation

This study shows that leptin signaling inhibition protects against Yersinia pseudotuberculosis infection by increasing host-pathogen cooperation, not resistance, through increased liver damage and dysfunction.

Microbiota control of maternal behavior regulates early postnatal growth of offspring

The paper identifies an E. coli strain that affects maternal behavior through microbiota-host interactions, leading to offspring growth stunting via impaired IGF-1 signaling.