Author

J. S. Bergholz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

J. J. Zhao· 2 shared Q. Wang· 2 shared T. Jiang· 2 shared H. Gu· 1 shared J. Lee· 1 shared J. M. Asara· 1 shared J. Ni· 1 shared J. Wu· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

J. J. Zhao

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2 papers

Recent·Most cited

Lysine vitcylation is a novel vitamin C-derived protein modification that enhances STAT1-mediated immune response

X. He, Y. Wei, J. Wu, Q. Wang, J. S. Bergholz, H. Gu, J. Zou, S. Lin, W. Wang, S. Xie, T. Jiang, J. Lee, J. M. Asara, K. Zhang, L. C. Cantley, J. J. Zhao

This study identifies vitcylation, a novel vitamin C-derived protein modification, and shows it enhances STAT1-mediated immune response by inhibiting PTPN2 interaction and increasing IFN pathway activation in tumor cells.

bioRxiv · Jun 27, 2023Biochemistry

Targeting EGFR in glioblastoma with a novel brain-penetrant small molecule EGFR-TKI

J. Ni, Y. Wang, Q. Wang, J. S. Bergholz, T. Jiang, T. M. Roberts, N. S. Gray, J. J. Zhao

This paper introduces a novel EGFR-TKI, CM93, which shows improved brain penetration and efficacy against EGFR-mutated glioblastoma in vitro and in vivo.

bioRxiv · Jan 9, 2021 · PreprintCancer Biology